Disruption of EGF Feedback by Intestinal Tumors and Neighboring Cells in Drosophila.
Drosophila
E-cadherin
JNK
apoptosis
homeostasis
midgut
rhomboid
stem cell
tumor
tumorigenesis
Journal
Current biology : CB
ISSN: 1879-0445
Titre abrégé: Curr Biol
Pays: England
ID NLM: 9107782
Informations de publication
Date de publication:
20 04 2020
20 04 2020
Historique:
received:
31
01
2019
revised:
11
12
2019
accepted:
29
01
2020
pubmed:
4
4
2020
medline:
16
7
2021
entrez:
4
4
2020
Statut:
ppublish
Résumé
In healthy adult organs, robust feedback mechanisms control cell turnover to enforce homeostatic equilibrium between cell division and death [1, 2]. Nascent tumors must subvert these mechanisms to achieve cancerous overgrowth [3-7]. Elucidating the nature of this subversion can reveal how cancers become established and may suggest strategies to prevent tumor progression. In adult Drosophila intestine, a well-studied model of homeostatic cell turnover, the linchpin of cell equilibrium is feedback control of the epidermal growth factor (EGF) protease Rhomboid (Rho). Expression of Rho in apoptotic cells enables them to secrete EGFs, which stimulate nearby stem cells to undergo replacement divisions [8]. As in mammals, loss of adenomatous polyposis coli (APC) causes Drosophila intestinal stem cells to form adenomas [9]. Here, we demonstrate that Drosophila APC
Identifiants
pubmed: 32243854
pii: S0960-9822(20)30162-7
doi: 10.1016/j.cub.2020.01.082
pmc: PMC7409949
mid: NIHMS1568956
pii:
doi:
Substances chimiques
Epidermal Growth Factor
62229-50-9
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
1537-1546.e3Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM116000
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Interests The authors declare no competing interests.