Aryl Hydrocarbon Receptor Activation and Tissue Factor Induction by Fluid Shear Stress and Indoxyl Sulfate in Endothelial Cells.
Basic Helix-Loop-Helix Transcription Factors
Cyclooxygenase 2
/ genetics
Cytochrome P-450 CYP1A1
/ genetics
Cytochrome P-450 CYP1B1
/ genetics
Gene Expression Regulation
Gene Knockdown Techniques
Human Umbilical Vein Endothelial Cells
/ metabolism
Humans
Indican
/ agonists
RNA, Messenger
/ metabolism
Receptors, Aryl Hydrocarbon
/ drug effects
Renal Insufficiency, Chronic
/ metabolism
Stress, Mechanical
Thromboplastin
/ drug effects
aryl hydrocarbon receptor
chronic kidney disease
indoxyl sulfate
shear stress
tissue factor
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
31 Mar 2020
31 Mar 2020
Historique:
received:
02
03
2020
revised:
25
03
2020
accepted:
29
03
2020
entrez:
5
4
2020
pubmed:
5
4
2020
medline:
5
1
2021
Statut:
epublish
Résumé
Endogenous agonists of the transcription factor aryl hydrocarbon receptor (AHR) such as the indolic uremic toxin, indoxyl sulfate (IS), accumulate in patients with chronic kidney disease. AHR activation by indolic toxins has prothrombotic effects on the endothelium, especially via tissue factor (TF) induction. In contrast, physiological AHR activation by laminar shear stress (SS) is atheroprotective. We studied the activation of AHR and the regulation of TF by IS in cultured human umbilical vein endothelial cells subjected to laminar fluid SS (5 dynes/cm2). SS and IS markedly increased the expression of AHR target genes
Identifiants
pubmed: 32244284
pii: ijms21072392
doi: 10.3390/ijms21072392
pmc: PMC7178278
pii:
doi:
Substances chimiques
AHR protein, human
0
Basic Helix-Loop-Helix Transcription Factors
0
RNA, Messenger
0
Receptors, Aryl Hydrocarbon
0
Thromboplastin
9035-58-9
CYP1A1 protein, human
EC 1.14.14.1
CYP1B1 protein, human
EC 1.14.14.1
Cytochrome P-450 CYP1A1
EC 1.14.14.1
Cytochrome P-450 CYP1B1
EC 1.14.14.1
Cyclooxygenase 2
EC 1.14.99.1
PTGS2 protein, human
EC 1.14.99.1
Indican
N187WK1Y1J
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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