Early Radiation-Induced Sarcoma in an Adolescent Treated for Relapsed Hodgkin Lymphoma with Nivolumab.
Hodgkin lymphoma
Nivolumab
children
obesity
post-radiation sarcoma
Journal
Medicina (Kaunas, Lithuania)
ISSN: 1648-9144
Titre abrégé: Medicina (Kaunas)
Pays: Switzerland
ID NLM: 9425208
Informations de publication
Date de publication:
31 Mar 2020
31 Mar 2020
Historique:
received:
19
01
2020
revised:
04
03
2020
accepted:
25
03
2020
entrez:
5
4
2020
pubmed:
5
4
2020
medline:
15
12
2020
Statut:
epublish
Résumé
Radiation-induced sarcoma (RIS) has been reported as a late secondary malignancy following radiotherapy for various types of cancer with a median latency of 10 years. We describe an early RIS that developed in an adolescent within three years of treatment (including PD-L1 check-point inhibitor Nivolumab) of a relapsed classic Hodgkin lymphoma (HL) and was diagnosed post-mortem. The patient died of the progressive RIS that was misleadingly assumed to be a resistant HL based on the positive PET/CT scan. Repetitive tumor biopsies are warranted in cases of aggressive and multi-drug resistant HL to validate imaging findings, ensure correct diagnosis and avoid overtreatment.
Identifiants
pubmed: 32244416
pii: medicina56040155
doi: 10.3390/medicina56040155
pmc: PMC7230437
pii:
doi:
Substances chimiques
Antineoplastic Agents, Immunological
0
Nivolumab
31YO63LBSN
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Références
Pediatr Blood Cancer. 2013 Dec;60(12):2042-6
pubmed: 23955975
J Clin Oncol. 2007 Apr 20;25(12):1489-97
pubmed: 17372278
Oncologist. 2017 May;22(5):585-591
pubmed: 28438889
AJR Am J Roentgenol. 2008 Jun;190(6):1611-5
pubmed: 18492914
J Clin Endocrinol Metab. 2000 Sep;85(9):3227-32
pubmed: 10999813
Br J Cancer. 2019 Apr;120(7):768-770
pubmed: 30808991
J Clin Oncol. 1998 Feb;16(2):536-44
pubmed: 9469338
Cancer Causes Control. 2013 Feb;24(2):287-95
pubmed: 23208661
AJR Am J Roentgenol. 2014 Jun;202(6):W521-31
pubmed: 24848845
Cancer Epidemiol Biomarkers Prev. 2019 Oct;28(10):1612-1620
pubmed: 31337641
J Clin Oncol. 2015 Sep 20;33(27):2975-85
pubmed: 26304892
Eur Radiol. 2015 Dec;25(12):3480-7
pubmed: 25994192
Immunohorizons. 2017 Jun 1;1(4):20-28
pubmed: 29202127
J Clin Oncol. 2010 Apr 20;28(12):2064-9
pubmed: 20308666
Cancer J. 2009 Mar-Apr;15(2):164-8
pubmed: 19390314
Klin Padiatr. 2016 Nov;228(6-07):286-293
pubmed: 27846658
Front Pediatr. 2014 Jun 05;2:53
pubmed: 24926474
Ann Nucl Med. 2017 Nov;31(9):660-668
pubmed: 28741053
Ann Oncol. 2008 Jul;19(7):1312-9
pubmed: 18356139
Clin Nucl Med. 2002 Oct;27(10):695-7
pubmed: 12352108
Adipocyte. 2019 Dec;8(1):304-317
pubmed: 31334678
J Natl Cancer Inst. 2002 Feb 6;94(3):182-92
pubmed: 11830608
Am J Hematol. 2018 May;93(5):704-715
pubmed: 29634090
Skeletal Radiol. 1987;16(7):524-32
pubmed: 2827314
Pediatr Blood Cancer. 2019 Mar;66(3):e27539
pubmed: 30426671
JAMA. 2003 Jul 23;290(4):465-75
pubmed: 12876089
Leuk Lymphoma. 2016 May;57(5):1140-8
pubmed: 26453440
J Clin Oncol. 2010 Mar 1;28(7):1232-9
pubmed: 20124178