Role of Vitamin D in Preventing and Treating Selected Extraskeletal Diseases-An Umbrella Review.
Acute Disease
Cognitive Dysfunction
/ prevention & control
Cohort Studies
Dementia
/ prevention & control
Depression
/ prevention & control
Dietary Supplements
Humans
Negative Results
Prospective Studies
Randomized Controlled Trials as Topic
Respiratory Tract Infections
/ prevention & control
Risk
Systematic Reviews as Topic
Vitamin D
/ administration & dosage
25-hydroxyvitamin D (25(OH)D), asthma
ARI
COPD
T1DM
dementia and cognitive decline
depression
multiple sclerosis
umbrella review
vitamin D
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
31 Mar 2020
31 Mar 2020
Historique:
received:
21
02
2020
revised:
24
03
2020
accepted:
25
03
2020
entrez:
5
4
2020
pubmed:
5
4
2020
medline:
29
12
2020
Statut:
epublish
Résumé
Evidence is accumulating that vitamin D may have beneficial effects on respiratory tract, autoimmune, neuro-degenerative, and mental diseases. The present umbrella review of systematic reviews (SRs) of cohort studies and randomised controlled trials (RCTs), plus single Mendelian randomisation studies aims to update current knowledge on the potential role of vitamin D in preventing and treating these extraskeletal diseases. Altogether, 73 SRs were identified. Observational data on primary prevention suggest an inverse association between vitamin D status and the risk of acute respiratory tract infections (ARI), dementia and cognitive decline, and depression, whereas studies regarding asthma, multiple sclerosis (MS), and type 1 diabetes mellitus (T1DM) are scarce. SRs of RCTs support observational data only for the risk of ARI. No respective RCTs are available for the prevention of chronic obstructive pulmonary disease (COPD), MS, and T1DM. SRs of RCTs indicate beneficial therapeutic effects in vitamin D-deficient patients with asthma and COPD, while effects on major depression and T1DM need to be further elucidated. Mendelian randomisation studies do not consistently support the results of SRs. Since several limitations of the included SRs and existing RCTs do not permit definitive conclusions regarding vitamin D and the selected diseases, further high-quality RCTs are warranted.
Identifiants
pubmed: 32244496
pii: nu12040969
doi: 10.3390/nu12040969
pmc: PMC7231149
pii:
doi:
Substances chimiques
Vitamin D
1406-16-2
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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