Factors Influencing Epigenetic Mechanisms: Is There A Role for Bariatric Surgery?
bariatric surgery
epigenetics
gene regulation
obesity
Journal
High-throughput
ISSN: 2571-5135
Titre abrégé: High Throughput
Pays: Switzerland
ID NLM: 101712192
Informations de publication
Date de publication:
20 Mar 2020
20 Mar 2020
Historique:
received:
16
02
2020
revised:
17
03
2020
accepted:
18
03
2020
entrez:
5
4
2020
pubmed:
5
4
2020
medline:
5
4
2020
Statut:
epublish
Résumé
Epigenetics is the interaction between the genome and environmental stimuli capable of influencing gene expression during development and aging. A large number of studies have shown that metabolic diseases are highly associated with epigenetic alterations, suggesting that epigenetic factors may play a central role in obesity. To investigate these relationships, we focus our attention on the most common epigenetic modifications that occur in obesity, including DNA methylation and post-translational modifications of histones. We also consider bariatric surgery as an epigenetic factor, evaluating how the anatomic and physiologic modifications induced by these surgical techniques can change gene expression. Here we discuss the importance of epigenetic mechanisms in chronic disease and cancer, and the role of epigenetic disturbances in obesity, with a focus on the role of bariatric surgery.
Identifiants
pubmed: 32244851
pii: ht9010006
doi: 10.3390/ht9010006
pmc: PMC7151212
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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