Thymosin β4-Enhancing Therapeutic Efficacy of Human Adipose-Derived Stem Cells in Mouse Ischemic Hindlimb Model.
Animals
Cell Differentiation
/ drug effects
Cell Movement
/ drug effects
Cell Transplantation
Disease Models, Animal
Gene Expression Regulation
/ drug effects
Hindlimb
/ blood supply
Humans
Ischemia
/ genetics
MAP Kinase Signaling System
/ genetics
Male
Mesenchymal Stem Cells
/ cytology
Mice
Mice, Nude
Neovascularization, Physiologic
/ genetics
Phosphatidylinositol 3-Kinases
/ metabolism
Proto-Oncogene Proteins c-akt
/ metabolism
TOR Serine-Threonine Kinases
/ metabolism
Thymosin
/ genetics
Wound Healing
/ genetics
Adipose-derived stem cells
Endothelial Differentiation
Hindlimb ischemia
Thymosin β4
Vascularization
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
21 Mar 2020
21 Mar 2020
Historique:
received:
02
03
2020
revised:
19
03
2020
accepted:
19
03
2020
entrez:
5
4
2020
pubmed:
5
4
2020
medline:
14
1
2021
Statut:
epublish
Résumé
Thymosin β4 (Tβ4) is a G-actin sequestering protein that contributes to diverse cellular activities, such as migration and angiogenesis. In this study, the beneficial effects of combined cell therapy with Tβ4 and human adipose-derived stem cells (hASCs) in a mouse ischemic hindlimb model were investigated. We observed that exogenous treatment with Tβ4 enhanced endogenous
Identifiants
pubmed: 32245208
pii: ijms21062166
doi: 10.3390/ijms21062166
pmc: PMC7139370
pii:
doi:
Substances chimiques
thymosin beta(4)
549LM7U24W
Thymosin
61512-21-8
Proto-Oncogene Proteins c-akt
EC 2.7.11.1
TOR Serine-Threonine Kinases
EC 2.7.11.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Research Foundation of Korea
ID : NRF-2016R1A6A3A11930414
Organisme : National Research Foundation of Korea
ID : NRF-2019R1I1A1A01056103
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