Emetine, Ipecac, Ipecac Alkaloids and Analogues as Potential Antiviral Agents for Coronaviruses.
COVID-19
MERS
SARS
coronavirus
dehydroemetine
emetine
ipecac
repurposing: antiviral
treatment
Journal
Pharmaceuticals (Basel, Switzerland)
ISSN: 1424-8247
Titre abrégé: Pharmaceuticals (Basel)
Pays: Switzerland
ID NLM: 101238453
Informations de publication
Date de publication:
21 Mar 2020
21 Mar 2020
Historique:
received:
01
03
2020
revised:
19
03
2020
accepted:
20
03
2020
entrez:
5
4
2020
pubmed:
5
4
2020
medline:
5
4
2020
Statut:
epublish
Résumé
The COVID-19 coronavirus is currently spreading around the globe with limited treatment options available. This article presents the rationale for potentially using old drugs (emetine, other ipecac alkaloids or analogues) that have been used to treat amoebiasis in the treatment of COVID-19. Emetine had amongst the lowest reported half-maximal effective concentration (EC
Identifiants
pubmed: 32245264
pii: ph13030051
doi: 10.3390/ph13030051
pmc: PMC7151655
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
Expert Opin Drug Metab Toxicol. 2008 Nov;4(11):1371-8
pubmed: 18950279
Arch Dis Child. 1966 Oct;41(219):549-50
pubmed: 5957731
Ann Allergy. 1987 Dec;59(6 Pt 2):20-4
pubmed: 2892445
Br J Clin Pharmacol. 1996 Feb;41(2):125-8
pubmed: 8838438
JAMA. 1980 May 16;243(19):1927-8
pubmed: 6102612
J Viral Hepat. 2011 Apr;18(4):245-51
pubmed: 20384961
Expert Rev Anti Infect Ther. 2017 May;15(5):483-492
pubmed: 28286997
J Virol. 2019 May 29;93(12):
pubmed: 30918074
Ther Drug Monit. 2000 Oct;22(5):566-73
pubmed: 11034262
BMC Infect Dis. 2016 Apr 21;16:174
pubmed: 27097824
Psychopharmacology (Berl). 1981;74(2):170-2
pubmed: 6791222
Ann Clin Microbiol Antimicrob. 2004 Dec 21;3:27
pubmed: 15610563
Eur J Drug Metab Pharmacokinet. 2002 Jan-Mar;27(1):17-27
pubmed: 11996323
PLoS Pathog. 2016 Jun 23;12(6):e1005717
pubmed: 27336364
Molecules. 2015 Jun 22;20(6):11474-89
pubmed: 26111177
Antimicrob Agents Chemother. 2014 Aug;58(8):4885-93
pubmed: 24841273
Antivir Ther. 2009;14(7):1001-4
pubmed: 19918104
Antimicrob Agents Chemother. 2015 Jan;59(1):742-4
pubmed: 25331705
Clin Cardiol. 1998 Oct;21(10):780-3
pubmed: 9789704
Curr Med Res Opin. 2006 Dec;22(12):2355-64
pubmed: 17257450
J Infect Dis. 2015 Dec 15;212(12):1904-13
pubmed: 26198719
Ann Emerg Med. 1984 Dec;13(12):1100-2
pubmed: 6150666
Pharmacopsychiatry. 2011 Sep;44(6):195-235
pubmed: 21969060
J R Coll Physicians Edinb. 2008 Dec;38(4):355-60
pubmed: 19227966
Jpn J Pharmacol. 2002 Jun;89(2):113-9
pubmed: 12120752
Cancer. 2018 Apr 15;124(8):1660-1672
pubmed: 29370463
Clin Pharmacol Ther. 1993 Jul;54(1):53-7
pubmed: 8101150
Am J Trop Med Hyg. 1965 Jan;14:78-83
pubmed: 14248995
Antimicrob Agents Chemother. 2010 Mar;54(3):1186-92
pubmed: 20086162
Eur J Drug Metab Pharmacokinet. 2002 Jan-Mar;27(1):29-35
pubmed: 11996324
J Infect. 2013 Dec;67(6):606-16
pubmed: 24096239
Eur J Clin Pharmacol. 2008 Jul;64(7):683-90
pubmed: 18415093
Cell Discov. 2018 Jun 5;4:31
pubmed: 29872540
Br J Clin Pharmacol. 1983 Mar;15(3):287-93
pubmed: 6849764
Pharmacol Ther. 1980;10(1):15-26
pubmed: 6996003