Berbamine ameliorates ethanol-induced liver injury by inhibition of hepatic inflammation in mice.
Animals
Benzylisoquinolines
/ pharmacology
Chemical and Drug Induced Liver Injury, Chronic
/ drug therapy
Cholesterol
/ blood
Cytokines
/ metabolism
Ethanol
/ adverse effects
Female
Hepatocytes
/ drug effects
Inflammation
/ drug therapy
Lipid Metabolism
Liver
/ drug effects
MAP Kinase Signaling System
Mice
Mice, Inbred C57BL
NF-kappa B
/ metabolism
RAW 264.7 Cells
STAT3 Transcription Factor
/ metabolism
Triglycerides
/ blood
Berbamine
Ethanol
Hepatic injury
Inflammation
NF-κB
Journal
Chinese journal of natural medicines
ISSN: 1875-5364
Titre abrégé: Chin J Nat Med
Pays: China
ID NLM: 101504416
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
received:
28
11
2019
entrez:
5
4
2020
pubmed:
5
4
2020
medline:
9
4
2020
Statut:
ppublish
Résumé
Alcoholic liver disease (ALD) has become one of the leading causes of death in the world. Berbamine (BM), a natural product mainly derived from Berberis vulgaris L, possesses multiple bioactivities as a traditional medicine. However, the protective effect of BM on ALD remains unknown. In this study, we investigated the effect of BM on ethanol-induced hepatic injury in mice and its underlying mechanism. It was shown that BM at 0.3125-40 μmol·L
Identifiants
pubmed: 32245588
pii: S1875-5364(20)30020-0
doi: 10.1016/S1875-5364(20)30020-0
pii:
doi:
Substances chimiques
Benzylisoquinolines
0
Cytokines
0
NF-kappa B
0
STAT3 Transcription Factor
0
Stat3 protein, mouse
0
Triglycerides
0
Ethanol
3K9958V90M
Cholesterol
97C5T2UQ7J
berbamine
V5KM4XJ0WM
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
186-195Informations de copyright
Copyright © 2020 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.