Implantable self-aligning fiber-optic optomechanical devices for in vivo intraocular pressure-sensing in artificial cornea.
Fabry-Perot
OCT
glaucoma
implant
keratoprosthesis
optical sensor
pressure
Journal
Journal of biophotonics
ISSN: 1864-0648
Titre abrégé: J Biophotonics
Pays: Germany
ID NLM: 101318567
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
02
02
2020
revised:
20
03
2020
accepted:
23
03
2020
pubmed:
5
4
2020
medline:
24
6
2021
entrez:
5
4
2020
Statut:
ppublish
Résumé
Artificial cornea is an effective treatment of corneal blindness. Yet, intraocular pressure (IOP) measurements for glaucoma monitoring remain an urgent unmet need. Here, we present the integration of a fiber-optic Fabry-Perot pressure sensor with an FDA-approved keratoprosthesis for real-time IOP measurements using a novel strategy based on optical-path self-alignment with micromagnets. Additionally, an alternative noncontact sensor-interrogation approach is demonstrated using a bench-top optical coherence tomography system. We show stable pressure readings with low baseline drift (<2.8 mm Hg) for >4.5 years in vitro and efficacy in IOP interrogation in vivo using fiber-optic self-alignment, with good initial agreement with the actual IOP. Subsequently, IOP drift in vivo was due to retroprosthetic membrane (RPM) formation on the sensor secondary to surgical inflammation (more severe in the current pro-fibrotic rabbit model). This study paves the way for clinical adaptation of optical pressure sensors with ocular implants, highlighting the importance of controlling RPM in clinical adaptation.
Identifiants
pubmed: 32246524
doi: 10.1002/jbio.202000031
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e202000031Subventions
Organisme : NEI NIH HHS
ID : P30EY003790
Pays : United States
Organisme : NIBIB NIH HHS
ID : P41 EB015903
Pays : United States
Informations de copyright
© 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Références
M. A. Klufas, C. E. Starr, Boston Keratoprosthesis (KPro), http://eyewiki.aao.org/Boston_Keratoprosthesis_(KPro) 2017.
H. F. Chew, B. D. Ayres, K. M. Hammersmith, C. J. Rapuano, P. R. Laibson, J. S. Myers, Y. P. Jin, E. J. Cohen, Cornea 2009, 28(9), 989.
C. H. Dohlman, M. Harissi-Dagher, J. Graney, Digit. J. Ophthalmol. 2007, 13(3).
W. B. Lee, R. M. Shtein, S. C. Kaufman, S. X. Deng, M. I. Rosenblatt, Ophthalmology 2015, 122(7), 1504.
K. M. Goins, A. S. Kitzmann, M. A. Greiner, Y. H. Kwon, W. L. M. Alward, J. Ledolter, M. D. Wagoner, Cornea 2016, 35(9), 1165.
C. J. Rudnisky, M. W. Belin, R. Guo, J. B. Ciolino, C. H. Dohlman, J. Aquavella, M. W. Belin, A. J. Aldave, S. B. Hannush, K. C. Sippel, M. J. Mannis, N. A. Afshari, T. T. Shen, E. C. Alfonso, M. S. Macsai, G. Tabin, K. H. Baratz, R. K. Hemady, J. C. Abad, S. A. Melki, R. Pineda, Am. J. Ophthalmol. 2016, 162, 89 e1.
A. Cruzat, A. Tauber, A. Shukla, E. I. Paschalis, R. Pineda, C. H. Dohlman, J. Ophthalmol. 2013, 2013, 686587.
R. N. Weinreb, T. Aung, F. A. Medeiros, JAMA 2014, 311(18), 1901.
T. S. Vajaranant, J. Liu, J. Wilensky, M. S. Cortina, A. A. Aref, Curr. Ophthalmol. Rep. 2016, 4(3), 147.
É. Pinet, J. Sensors 2009, 2009, 1.
É. Pinet, Int. Soc. Opt. Photon 2011, 7753, 775304.
C. Ma, A. Wang, Appl. Optics 2013, 52(2), 127.
Y. Zhu, A. Wang, IEEE Photon. Technol. Lett. 2005, 17(2), 447.
C. Belleville, G. Duplain, Opt. Lett. 1993, 18(1), 78.
B. L. Zerbe, M. W. Belin, J. B. Ciolino, Boston Type 1 Keratoprosthesis Study Group, Ophthalmology 2006, 113(10), 1779 e1-7.
E. I. Paschalis, C. Zhou, F. Lei, N. Scott, V. Kapoulea, M. C. Robert, D. Vavvas, R. Dana, J. Chodosh, C. H. Dohlman, Am. J. Pathol. 2017, 187(6), 1327.
A. Crnej, E. I. Paschalis, B. Salvador-Culla, A. Tauber, B. Drnovsek-Olup, L. Q. Shen, C. H. Dohlman, Cornea 2014, 33(4), 349.
B. L. Zerbe, M. W. Belin, J. B. Ciolino, Boston Type 1 Keratoprosthesis Study Group, Adv. Healthc. Mater. 2017, 6(4), 1601356.
K. Mansouri, T. Shaarawy, Br. J. Ophthalmol. 2011, 95(5), 627.
S. Melki, A. Todani, G. Cherfan, JAMA Ophthalmol. 2014, 132(10), 1221.
I. E. Araci, B. Su, S. R. Quake, Y. Mandel, Nat. Med. 2014, 20(9), 1074.
S. Mariacher, M. Ebner, J. Hurst, P. Szurman, K. Januschowski, Exp. Eye Res. 2018, 166, 84.
A. Koutsonas, P. Walter, G. Roessler, N. Plange, Invest. Ophthalmol. Vis. Sci. 2015, 56(2), 1063.
V. Narasimhan, R. H. Siddique, J. O. Lee, S. Kumar, B. Ndjamen, J. du, N. Hong, D. Sretavan, H. Choo, Nat. Nanotechnol. 2018, 13(6), 512.
A. Koutsonas, P. Walter, D. Kuerten, N. Plange, Biomed. Res. Int. 2018, 2018, 4024198.
W. Lee, Y. Jung, H. Jung, C. Seo, H. Choo, H. Lee, Micromachines (Basel) 2018, 10(1), 12.
A. Todani, I. Behlau, M. A. Fava, F. Cade, D. G. Cherfan, F. R. Zakka, F. A. Jakobiec, Y. Gao, C. H. Dohlman, S. A. Melki, Invest. Ophthalmol. Vis. Sci. 2011, 52(13), 9573.
L. Yu, B. J. Kim, E. Meng, Sensors (Basel) 2014, 14(11), 20620.
B. S. Klosterhoff, M. Tsang, D. She, K. G. Ong, M. G. Allen, N. J. Willett, R. E. Guldberg, J. Biomech. Eng. 2017, 139(2), 021009:1-11.
M. Gao, W. Sang, F. Liu, H. Yu, R. Zhou, M. W. Belin, P. Zloty, Y. Chen, J. Ophthalmol. 2016, 2016, 1094279.
R. K. Talati, J. A. Hallak, F. I. Karas, J. de la Cruz, M. S. Cortina, Cornea 2018, 37(2), 145.
C. J. Rudnisky, M. W. Belin, A. Todani, K. al-Arfaj, J. D. Ament, B. J. Zerbe, J. B. Ciolino, Boston Type 1 Keratoprosthesis Study Group, Ophthalmology 2012, 119(5), 951.
G. Chak, J. V. Aquavella, Cornea 2010, 29(10), 1169.
D. Woolf, P. C. Hui, E. Iwase, M. Khan, A. W. Rodriguez, P. Deotare, I. Bulu, S. G. Johnson, F. Capasso, M. Loncar, Opt. Express 2013, 21(6), 7258.
P.-C. Hui, D. Woolf, E. Iwase, Y. I. Sohn, D. Ramos, M. Khan, A. W. Rodriguez, S. G. Johnson, F. Capasso, M. Loncar, Appl. Phys. Lett. 2013, 103(2), 021102.
A. Sokol, T. I. Bertelsen, N. Teigland, Acta Ophthalmol. 1977, 55(2), 317.
E. P. Ivanova, J. Hasan, H. K. Webb, G. Gervinskas, S. Juodkazis, V. K. Truong, A. H. F. Wu, R. N. Lamb, V. A. Baulin, G. S. Watson, J. A. Watson, D. E. Mainwaring, R. J. Crawford, Nat. Commun. 2013, 4, 2838.
G. Liu, Q. Sheng, D. Dam, J. Hua, W. Hou, M. Han, Opt. Lett. 2017, 42(7), 1412.
C. H. Dohlman, C. Zhou, F. Lei, F. Cade, C. V. Regatieri, A. Črnej, J. G. Dohlman, L. Q. Shen, E. I. Paschalis, Cornea 2019, 38(12), 1589.
C. H. Dohlman, F. Cade, C. V. Regatieri, C. Zhou, F. Lei, A. Crnej, M. Harissi-Dagher, M. C. Robert, G. N. Papaliodis, D. Chen, J. V. Aquavella, E. K. Akpek, A. J. Aldave, K. C. Sippel, D. J. DʼAmico, J. G. Dohlman, P. Fagerholm, L. Wang, L. Q. Shen, M. González-Andrades, J. Chodosh, K. R. Kenyon, C. S. Foster, R. Pineda, S. Melki, K. A. Colby, J. B. Ciolino, D. G. Vavvas, S. Kinoshita, R. Dana, E. I. Paschalis, Cornea 2018, 37(2), 248.
C. H. Dohlman, M.-C. Robert, E. I. Paschalis, Treatment of Chemical Burn to the Eye: A Changing Picture, Springer, Cham 2020, p. 109.
E. I. Paschalis, F. Lei, C. Zhou, V. Kapoulea, R. Dana, J. Chodosh, D. G. Vavvas, C. H. Dohlman, Proc. Natl. Acad. Sci. U. S. A. 2018, 115(48), E11359.
E. I. Paschalis, F. Lei, C. Zhou, X. N. Chen, V. Kapoulea, P. C. Hui, R. Dana, J. Chodosh, D. G. Vavvas, C. H. Dohlman, J. Immunol. 2019, 202(2), 539.
E. I. Paschalis, F. Lei, C. Zhou, V. Kapoulea, A. Thanos, R. Dana, D. G. Vavvas, J. Chodosh, C. H. Dohlman, Am. J. Pathol. 2018, 188(7), 1580.
E. I. Paschalis, E. V. Taniguchi, J. Chodosh, L. R. Pasquale, K. Colby, C. H. Dohlman, L. Q. Shen, Curr. Eye Res. 2019, 44(6), 599.
E. V. Taniguchi, E. I. Paschalis, A. Crnej, A. Ren, K. A. Colby, J. Chodosh, L. R. Pasquale, L. Q. Shen, C. H. Dohlman, A. Cruzat, Cornea 2017, 36(9), 1096.