Role of activin receptor-like kinase 1 in vascular development and cerebrovascular diseases.
activin receptor-like kinase 1
aneurysm
atherosclerotic plaque
endoglin
extracellular matrix protein
intracranial arteriovenous malformation
matrix metalloproteinase
pericyte
transforming growth factor beta 1 pathway
vascular development
Journal
Neural regeneration research
ISSN: 1673-5374
Titre abrégé: Neural Regen Res
Pays: India
ID NLM: 101316351
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
entrez:
5
4
2020
pubmed:
5
4
2020
medline:
5
4
2020
Statut:
ppublish
Résumé
Activin receptor-like kinase 1 (ALK1) is a transmembrane serine/threonine receptor kinase of the transforming growth factor beta (TGFβ) receptor superfamily. ALK1 is specifically expressed in vascular endothelial cells, and its dynamic changes are closely related to the proliferation of endothelial cells, the recruitment of pericytes to blood vessels, and functional differentiation during embryonic vascular development. The pathophysiology of many cerebrovascular diseases is today understood as a disorder of endothelial cell function and an imbalance in the proportion of vascular cells. Indeed, mutations in ALK1 and its co-receptor endoglin are major genetic risk factors for vascular arteriovenous malformation. Many studies have shown that ALK1 is closely related to the development of cerebral aneurysms, arteriovenous malformations, and cerebral atherosclerosis. In this review, we describe the various roles of ALK1 in the regulation of angiogenesis and in the maintenance of cerebral vascular homeostasis, and we discuss its relationship to functional dysregulation in cerebrovascular diseases. This review should provide new perspectives for basic research on cerebrovascular diseases and offer more effective targets and strategies for clinical diagnosis, treatment, and prevention.
Identifiants
pubmed: 32246621
pii: NeuralRegenRes_2020_15_10_1807_280305
doi: 10.4103/1673-5374.280305
pmc: PMC7513971
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1807-1813Déclaration de conflit d'intérêts
None
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