A potent photoreactive general anesthetic with novel binding site selectivity for GABA
Allosteric Regulation
/ drug effects
Anesthetics, General
/ chemical synthesis
Animals
Binding Sites
/ drug effects
Dose-Response Relationship, Drug
HEK293 Cells
Humans
Models, Molecular
Molecular Structure
Photochemical Processes
Propofol
/ chemical synthesis
Receptors, GABA-A
/ metabolism
Structure-Activity Relationship
Xenopus
Diazirine
GABA-A receptor
General anesthetics binding sites
Photolabeling
Positive allosteric modulator
Transmembrane domain
Journal
European journal of medicinal chemistry
ISSN: 1768-3254
Titre abrégé: Eur J Med Chem
Pays: France
ID NLM: 0420510
Informations de publication
Date de publication:
15 May 2020
15 May 2020
Historique:
received:
13
02
2020
revised:
18
03
2020
accepted:
19
03
2020
pubmed:
5
4
2020
medline:
1
12
2020
entrez:
5
4
2020
Statut:
ppublish
Résumé
The pentameric γ-aminobutyric acid type A receptors (GABA
Identifiants
pubmed: 32247113
pii: S0223-5234(20)30228-2
doi: 10.1016/j.ejmech.2020.112261
pmc: PMC7342775
mid: NIHMS1581390
pii:
doi:
Substances chimiques
Anesthetics, General
0
Receptors, GABA-A
0
Propofol
YI7VU623SF
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
112261Subventions
Organisme : NIGMS NIH HHS
ID : P01 GM058448
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Masson SAS. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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