Centromeric RNA and Its Function at and Beyond Centromeric Chromatin.
centromeric RNA
centromeric chromatin
heterochromatin
satellite repeats
transcription
Journal
Journal of molecular biology
ISSN: 1089-8638
Titre abrégé: J Mol Biol
Pays: Netherlands
ID NLM: 2985088R
Informations de publication
Date de publication:
10 07 2020
10 07 2020
Historique:
received:
30
11
2019
revised:
26
03
2020
accepted:
27
03
2020
pubmed:
6
4
2020
medline:
23
1
2021
entrez:
6
4
2020
Statut:
ppublish
Résumé
The most fundamental region of the chromosome for maintaining accurate genome segregation and stability is the centromeric chromatin [1,2]. In this review, we will focus on centromere-derived RNAs (cenRNAs), a crucial component of centromere structure first identified over 40 years ago [3] but only recently investigated in detail. Indeed, centromeric transcription is necessary for the proper formation of CENP-A-containing centromeric chromatin (cen-chromatin) [4-7] and for the formation of pericentromeric heterochromatin [8,9], and the transcripts play a role in the structure and function of the centromere-kinetochore interface [3,7,10]. Furthermore, cenRNA overexpression has been observed in some cancer patients [11-13] and has been shown to drive the formation of breast cancer in a mouse model system [14]. Together, these observations call for a more detailed appraisal of the composition, regulation and function of cenRNAs. In this review, we will first discuss the difficulties underlying the study of cenRNAs, then we identify different domains within the centromeric chromatin before we discuss the role of cenRNAs in the context of these domains.
Identifiants
pubmed: 32247764
pii: S0022-2836(20)30262-X
doi: 10.1016/j.jmb.2020.03.027
pii:
doi:
Substances chimiques
Centromere Protein A
0
RNA
63231-63-0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
4257-4269Informations de copyright
Copyright © 2020. Published by Elsevier Ltd.