Thermosensitive hydrogels as sustained drug delivery system for CTLA-4 checkpoint blocking antibodies.

Antibodies, Blocking CTLA-4 Antigen Drug Carriers Drug Delivery Systems Humans Hydrogels Poloxamer Temperature
Cytotoxic T-lymphocyte-associated protein 4 Hydrogel Immune checkpoint blockade Immune related adverse event Poloxamer Sustained release

Journal

Journal of controlled release : official journal of the Controlled Release Society
ISSN: 1873-4995
Titre abrégé: J Control Release
Pays: Netherlands
ID NLM: 8607908

Informations de publication

Date de publication:
10 07 2020
Historique:
received: 03 12 2019
revised: 23 03 2020
accepted: 31 03 2020
pubmed: 6 4 2020
medline: 22 6 2021
entrez: 6 4 2020
Statut: ppublish

Résumé

Thermosensitive poloxamer 407 (P407) hydrogels were evaluated as slow release system for optimizing CTLA-4 therapy. Slow release reduces systemic antibody levels and potentially mitigates the side effects of CTLA-4 therapy. The 25% P407 hydrogel is injectable at room temperature and depots are established quickly after subcutaneous injection. Scanning electron microscopy revealed the porous structure of the hydrogel, average pore surface was 1335 μm

Identifiants

DOI: 10.1016/j.jconrel.2020.03.050 PMID: 32247805
pubmed: 32247805
pii: S0168-3659(20)30210-8
doi: 10.1016/j.jconrel.2020.03.050
pii:
doi:

Substances chimiques

Antibodies, Blocking 0
CTLA-4 Antigen 0
Drug Carriers 0
Hydrogels 0
Poloxamer 106392-12-5

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1-11

Informations de copyright

Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest A Chan is affiliated to Percuros B.V. as a founder. D Kralisch is affiliated to JeNaCell GmbH as a founder.

Auteurs

Chih Kit Chung (CK)

Department of Radiology, Division Translational Nanobiomaterials and Imaging, Leiden University Medical Center, Leiden, the Netherlands; Percuros B.V., Zernikedreef 8, 2333 CL Leiden, the Netherlands.

Marieke F Fransen (MF)

Department of Immunohematology and Bloodtransfusion, Leiden University Medical Center, Leiden, the Netherlands.

Koen van der Maaden (K)

Department of Immunohematology and Bloodtransfusion, Leiden University Medical Center, Leiden, the Netherlands; TECOdevelopment GmbH, Frankfurt, Germany.

Yaima Campos (Y)

Department of Radiology, Division Translational Nanobiomaterials and Imaging, Leiden University Medical Center, Leiden, the Netherlands; Department of Ceramic and Metallic Biomaterials, Biomaterials Center (BIOMAT), University of Havana, Havana, Cuba.

Jomarien García-Couce (J)

Department of Radiology, Division Translational Nanobiomaterials and Imaging, Leiden University Medical Center, Leiden, the Netherlands; Department of Polymeric Biomaterials, Biomaterials Center (BIOMAT), University of Havana, Havana, Cuba.

Dana Kralisch (D)

JeNaCell GmbH, Winzerlaer Straße 2, 07745 Jena, Germany.

Alan Chan (A)

Department of Radiology, Division Translational Nanobiomaterials and Imaging, Leiden University Medical Center, Leiden, the Netherlands; Percuros B.V., Zernikedreef 8, 2333 CL Leiden, the Netherlands.

Ferry Ossendorp (F)

Department of Immunohematology and Bloodtransfusion, Leiden University Medical Center, Leiden, the Netherlands.

Luis J Cruz (LJ)

Department of Radiology, Division Translational Nanobiomaterials and Imaging, Leiden University Medical Center, Leiden, the Netherlands. Electronic address: l.j.cruz_ricondo@lumc.nl.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps bloquants › Thermosensitive hydrogels as sustained drug...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Antigènes de différenciation › Antigènes de différenciation des lymphocytes T › Antigène CTLA-4 › Thermosensitive hydrogels as sustained drug...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Systèmes de délivrance de médicaments › Vecteurs de médicaments › Thermosensitive hydrogels as sustained drug...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Systèmes de délivrance de médicaments › Thermosensitive hydrogels as sustained drug...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Thermosensitive hydrogels as sustained drug...
questionsmedicales.fr › Préparations pharmaceutiques › Colloïdes › Gels › Hydrogels › Thermosensitive hydrogels as sustained drug...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › Polyéthylène glycols › Poloxamère › Thermosensitive hydrogels as sustained drug...
questionsmedicales.fr › Environnement et santé publique › Environnement › Concepts météorologiques › Atmosphère › Temps (météorologie) › Température › Thermosensitive hydrogels as sustained drug...