Gender differences in the effect of blackberry supplementation in vascular senescence and atherosclerosis in ApoE
Animals
Aorta
/ metabolism
Atherosclerosis
/ drug therapy
Cellular Senescence
/ drug effects
Dietary Supplements
Female
Male
Mice
Mice, Knockout, ApoE
Muscle, Smooth, Vascular
/ metabolism
Myocytes, Smooth Muscle
/ metabolism
NADPH Oxidase 1
/ metabolism
Oxidative Stress
Plant Extracts
/ administration & dosage
Plaque, Atherosclerotic
/ epidemiology
Reactive Oxygen Species
/ metabolism
Rubus
/ chemistry
Sex Factors
Atherosclerosis
Blackberry
Nox1
Polyphenols
VSMC
Journal
The Journal of nutritional biochemistry
ISSN: 1873-4847
Titre abrégé: J Nutr Biochem
Pays: United States
ID NLM: 9010081
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
15
11
2019
revised:
09
01
2020
accepted:
07
03
2020
pubmed:
6
4
2020
medline:
10
4
2021
entrez:
6
4
2020
Statut:
ppublish
Résumé
As the cardiovascular system ages, it becomes more vulnerable to the effects of oxidative stress and inflammation. The aging process, along with external factors such as radiation exposure and lifestyle, induces vascular senescence and accelerates atherosclerotic plaque accumulation. Expression of nicotinamide adenine dinucleotide phosphate oxidase 1 (Nox1), which produces superoxide, is associated with senescence in vascular smooth muscle cells in vitro and atherosclerosis in ApoE
Identifiants
pubmed: 32248057
pii: S0955-2863(19)31150-7
doi: 10.1016/j.jnutbio.2020.108375
pii:
doi:
Substances chimiques
Plant Extracts
0
Reactive Oxygen Species
0
NADPH Oxidase 1
EC 1.6.3.-
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
108375Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.