Role of intermediate-conductance calcium-activated potassium channels in atrial fibrillation in canines with rapid atrial pacing.
Atrial fibrillation
Canine
Intermediate-conductance Ca2+-activated K+ channels
Stellate ganglion
Journal
Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing
ISSN: 1572-8595
Titre abrégé: J Interv Card Electrophysiol
Pays: Netherlands
ID NLM: 9708966
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
received:
04
01
2020
accepted:
24
03
2020
pubmed:
6
4
2020
medline:
19
8
2021
entrez:
6
4
2020
Statut:
ppublish
Résumé
The aim of the present study was to explore the role of intermediate-conductance Ca Eighteen dogs were divided into the control group, the pacing group and the stellate ganglion ablation (SGA) + pacing group. In the pacing group, dogs were subjected to rapid atrial pacing, and the atrial effective refractory period (AERP) and AF inducibility were measured. After cessation of 7-h pacing, SK4 inhibitor (TRAM-34) was administered. After SGA, the SGA + pacing group received the same procedure of pacing and electrophysiological measurement as the pacing group. The expression of SK4 was measured in the left atrium (LA) and the right atrium (RA) in the three groups. The duration of the AERP decreased, while the number of AF episodes, the duration of induced AF, and the amplitude of stellate ganglion neural activity all increased after rapid atrial pacing. TRAM-34 completely inhibited AF induction in the pacing group. There was no significant difference in AERP shortening or AF vulnerability between the SGA + pacing group and the control group. The expression of SK4 in the LA and RA was higher in the pacing group than in the control and SGA + pacing groups. However, there was no significant difference in the expression of SK4 in the LA or the RA between the SGA + pacing group and the control group. The higher expression of SK4 plays an important role in AF induction and the increased expression of SK4 in the atrium is related to SG activity during rapid atrial pacing.
Identifiants
pubmed: 32248426
doi: 10.1007/s10840-020-00736-8
pii: 10.1007/s10840-020-00736-8
doi:
Substances chimiques
Intermediate-Conductance Calcium-Activated Potassium Channels
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
247-253Subventions
Organisme : National Natural Science Foundation of China
ID : 81670303 and 81970277
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