Effect of periodontal therapy on adipokine biomarkers in overweight.
chemerin
orosomucoid
overweight
periodontitis
retinol-binding protein 4
Journal
Journal of clinical periodontology
ISSN: 1600-051X
Titre abrégé: J Clin Periodontol
Pays: United States
ID NLM: 0425123
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
27
11
2019
revised:
21
02
2020
accepted:
24
03
2020
pubmed:
6
4
2020
medline:
5
3
2021
entrez:
6
4
2020
Statut:
ppublish
Résumé
The aim of this study was to evaluate the effect of non-surgical periodontal therapy on circulating levels of the systemic inflammation-associated biomarkers orosomucoid (ORM), high-sensitivity C-reactive protein (hsCRP), chemerin, and retinol-binding protein 4 (RBP4) in overweight or normal-weight patients with periodontitis at 27.5 months after therapy. This exploratory subanalysis includes patients from the ABPARO-trial (ClinicalTrials.gov NCT00707369). The per-protocol collective provided untreated periodontitis patients with high (≥28 kg/m At the 27.5-month examination, ORM and hsCRP decreased noticeably in the overweight group (ORM: p = .001, hsCRP: p = .004) and normal-weight patients (ORM: p = .007, hsCRP: p < .001). Chemerin decreased in the overweight group (p = .048), and RBP4 concentrations remained stable. Non-surgical periodontal therapy reduced systemically elevated inflammation-associated biomarkers in periodontitis patients. These improvements were more pronounced in overweight patients than in normal-weight patients.
Substances chimiques
Adipokines
0
Biomarkers
0
Chemokines
0
RARRES2 protein, human
0
RBP4 protein, human
0
Retinol-Binding Proteins, Plasma
0
C-Reactive Protein
9007-41-4
Banques de données
ClinicalTrials.gov
['NCT00707369']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
842-850Informations de copyright
© 2020 The Authors. Journal of Clinical Periodontology published by John Wiley & Sons Ltd.
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