Repetitive mTBI is associated with age-related reductions in cerebral blood flow but not cortical thickness.
accelerated aging
cerebral blood flow
cortical thickness
mild TBI
repetitive mTBI
Journal
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
ISSN: 1559-7016
Titre abrégé: J Cereb Blood Flow Metab
Pays: United States
ID NLM: 8112566
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
pubmed:
7
4
2020
medline:
29
7
2021
entrez:
7
4
2020
Statut:
ppublish
Résumé
Mild traumatic brain injury (mTBI) is a risk factor for Alzheimer's disease (AD), and evidence suggests cerebrovascular dysregulation initiates deleterious neurodegenerative cascades. We examined whether mTBI history alters cerebral blood flow (CBF) and cortical thickness in regions vulnerable to early AD-related changes. Seventy-four young to middle-aged Veterans (mean age = 34, range = 23-48) underwent brain scans. Participants were divided into: (1) Veteran Controls (
Identifiants
pubmed: 32248731
doi: 10.1177/0271678X19897443
pmc: PMC8369996
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
431-444Subventions
Organisme : NINDS NIH HHS
ID : F31 NS098704
Pays : United States
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