[Toxoplasmosis and behavioural changes (French translation of the article)].

Toxoplasmose et modifications du comportement humain.

Journal

Journal francais d'ophtalmologie
ISSN: 1773-0597
Titre abrégé: J Fr Ophtalmol
Pays: France
ID NLM: 7804128

Informations de publication

Date de publication:
May 2020
Historique:
received: 10 07 2019
revised: 29 07 2019
accepted: 20 08 2019
pubmed: 7 4 2020
medline: 2 10 2020
entrez: 7 4 2020
Statut: ppublish

Résumé

Nearly one-third of the planet's population is affected by T. gondii infection. In ophthalmology, toxoplasmosis is even considered to be the most common cause of posterior uveitis of infectious origin. Humans are only an intermediate host, and T. gondii needs to infect cats for its sexual reproduction. All the elements increasing the risk of predation by the definitive host are then favourable to the parasite. Numerous experimental animal model studies have shown that T. gondii infection is associated with predatory risk behaviours such as an attraction of infected mice to cat urine. Infection with the parasite is associated with a demethylation of the promoters of certain genes in the cerebral amygdala of the intermediate hosts, modifying dopaminergic circuits associated with fear. Similarly, T. gondii has been linked to behavioural changes in humans. Toxoplasma infection is classically associated with the frequency of schizophrenia, suicide attempts or "road rage." A more recent study shows that toxoplasma infection prevalence was a consistent, positive predictor of entrepreneurial activity. Fear of failure would be less important in infected individuals, who are more willing than others to start their own business. These elements shed interesting light on behaviours and their possible relationship with toxoplasmosis, which is generally considered benign in adults.

Identifiants

pubmed: 32248961
pii: S0181-5512(20)30108-X
doi: 10.1016/j.jfo.2019.08.028
pii:
doi:

Types de publication

Journal Article Review

Langues

fre

Sous-ensembles de citation

IM

Pagination

433-438

Informations de copyright

Copyright © 2020 Elsevier Masson SAS. All rights reserved.

Auteurs

T Desmettre (T)

Centre de rétine médicale, 187, rue de Menin, 59520 Marquette-Lez-Lille, France; Queen Anne Street Medical Centre, 18-22, Queen Anne Street, W1G 8Hun London, Royaume-Uni. Electronic address: thomas@desmettre.org.

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Classifications MeSH