Non-neural surface ectodermal rosette formation and F-actin dynamics drive mammalian neural tube closure.

Actins / analysis Animals DNA-Binding Proteins / genetics Ectoderm / abnormalities Mice Mutation Neural Tube / abnormalities Neural Tube Defects / embryology Neurulation Spinal Dysraphism / embryology Spine / abnormalities Transcription Factors / genetics
Computational visual modeling Convergent F-actin protrusions and cable network Grhl3-KO mice Multicellular rosette formation Non-neural surface ectodermal cells Posterior neuropore (PNP)

Journal

Biochemical and biophysical research communications
ISSN: 1090-2104
Titre abrégé: Biochem Biophys Res Commun
Pays: United States
ID NLM: 0372516

Informations de publication

Date de publication:
04 06 2020
Historique:
received: 09 03 2020
accepted: 24 03 2020
pubmed: 7 4 2020
medline: 15 12 2020
entrez: 7 4 2020
Statut: ppublish

Résumé

The mechanisms underlying mammalian neural tube closure remain poorly understood. We report a unique cellular process involving multicellular rosette formation, convergent cellular protrusions, and F-actin cable network of the non-neural surface ectodermal cells encircling the closure site of the posterior neuropore, which are demonstrated by scanning electron microscopy and genetic fate mapping analyses during mouse spinal neurulation. These unique cellular structures are severely disrupted in the surface ectodermal transcription factor Grhl3 mutants that exhibit fully penetrant spina bifida. We propose a novel model of mammalian neural tube closure driven by surface ectodermal dynamics, which is computationally visualized.

Identifiants

DOI: 10.1016/j.bbrc.2020.03.138 PMID: 32248972 PMC: PMC7210071
pubmed: 32248972
pii: S0006-291X(20)30635-5
doi: 10.1016/j.bbrc.2020.03.138
pmc: PMC7210071
mid: NIHMS1581680
pii:
doi:

Substances chimiques

Actins 0
DNA-Binding Proteins 0
Grhl3 protein, mouse 0
Transcription Factors 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

647-653

Subventions

Organisme : NIDCR NIH HHS
ID : R01 DE021696
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE026737
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS102261
Pays : United States

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Références

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Auteurs

Chengji J Zhou (CJ)

Institute for Pediatric Regenerative Medicine, Shriners Hospitals for Children & University of California at Davis, School of Medicine, Sacramento, CA, 95817, USA; Department of Biochemistry and Molecular Medicine, School of Medicine, University of California at Davis, Sacramento, CA, 95817, USA. Electronic address: cjzhou@ucdavis.edu.

Yu Ji (Y)

Institute for Pediatric Regenerative Medicine, Shriners Hospitals for Children & University of California at Davis, School of Medicine, Sacramento, CA, 95817, USA; Department of Biochemistry and Molecular Medicine, School of Medicine, University of California at Davis, Sacramento, CA, 95817, USA.

Kurt Reynolds (K)

Institute for Pediatric Regenerative Medicine, Shriners Hospitals for Children & University of California at Davis, School of Medicine, Sacramento, CA, 95817, USA; Department of Biochemistry and Molecular Medicine, School of Medicine, University of California at Davis, Sacramento, CA, 95817, USA.

Moira McMahon (M)

Institute for Pediatric Regenerative Medicine, Shriners Hospitals for Children & University of California at Davis, School of Medicine, Sacramento, CA, 95817, USA.

Michael A Garland (MA)

Institute for Pediatric Regenerative Medicine, Shriners Hospitals for Children & University of California at Davis, School of Medicine, Sacramento, CA, 95817, USA; Department of Biochemistry and Molecular Medicine, School of Medicine, University of California at Davis, Sacramento, CA, 95817, USA.

Shuwen Zhang (S)

Institute for Pediatric Regenerative Medicine, Shriners Hospitals for Children & University of California at Davis, School of Medicine, Sacramento, CA, 95817, USA; Department of Biochemistry and Molecular Medicine, School of Medicine, University of California at Davis, Sacramento, CA, 95817, USA.

Bo Sun (B)

Institute for Pediatric Regenerative Medicine, Shriners Hospitals for Children & University of California at Davis, School of Medicine, Sacramento, CA, 95817, USA; Department of Biochemistry and Molecular Medicine, School of Medicine, University of California at Davis, Sacramento, CA, 95817, USA.

Ran Gu (R)

Institute for Pediatric Regenerative Medicine, Shriners Hospitals for Children & University of California at Davis, School of Medicine, Sacramento, CA, 95817, USA; Department of Biochemistry and Molecular Medicine, School of Medicine, University of California at Davis, Sacramento, CA, 95817, USA.

Mohammad Islam (M)

Institute for Pediatric Regenerative Medicine, Shriners Hospitals for Children & University of California at Davis, School of Medicine, Sacramento, CA, 95817, USA.

Yue Liu (Y)

Institute for Pediatric Regenerative Medicine, Shriners Hospitals for Children & University of California at Davis, School of Medicine, Sacramento, CA, 95817, USA.

Tianyu Zhao (T)

Institute for Pediatric Regenerative Medicine, Shriners Hospitals for Children & University of California at Davis, School of Medicine, Sacramento, CA, 95817, USA.

Grace Hsu (G)

Department of Biochemistry, University of Utah, Salt Lake City, UT, 84112, USA.

Janet Iwasa (J)

Department of Biochemistry, University of Utah, Salt Lake City, UT, 84112, USA.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cytosquelette › Protéines des microfilaments › Actines › Non-neural surface ectodermal rosette...
questionsmedicales.fr › Eucaryotes › Animaux › Non-neural surface ectodermal rosette...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de liaison à l'ADN › Non-neural surface ectodermal rosette...
questionsmedicales.fr › Structures de l'embryon › Feuillets embryonnaires › Ectoderme › Non-neural surface ectodermal rosette...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Non-neural surface ectodermal rosette...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Non-neural surface ectodermal rosette...
questionsmedicales.fr › Structures de l'embryon › Tube neural › Non-neural surface ectodermal rosette...
questionsmedicales.fr › Malformations et maladies congénitales, héréditaires et néonatales › Malformations › Malformations du système nerveux › Anomalies du tube neural › Non-neural surface ectodermal rosette...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Morphogenèse › Neurulation › Non-neural surface ectodermal rosette...
questionsmedicales.fr › Malformations et maladies congénitales, héréditaires et néonatales › Malformations › Malformations du système nerveux › Anomalies du tube neural › Dysraphie spinale › Non-neural surface ectodermal rosette...
questionsmedicales.fr › Appareil locomoteur › Squelette › Rachis › Non-neural surface ectodermal rosette...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Non-neural surface ectodermal rosette...