Functional characterization of monocarboxylate transporter 12 (SLC16A12/MCT12) as a facilitative creatine transporter.
Creatine
Facilitated diffusion
Facilitative transport
MCT12
Transporter
Journal
Drug metabolism and pharmacokinetics
ISSN: 1880-0920
Titre abrégé: Drug Metab Pharmacokinet
Pays: England
ID NLM: 101164773
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
08
12
2019
revised:
27
01
2020
accepted:
27
01
2020
pubmed:
7
4
2020
medline:
23
12
2020
entrez:
7
4
2020
Statut:
ppublish
Résumé
SLC16A12/MCT12 has been recently identified as a creatine transporter in a Xenopus oocyte expression system; however, the mechanism, by which MCT12 transports creatine, remains unclear. This study was performed to determine the functional and molecular characteristics of MCT12 in mammalian cells. The results showed that the uptake of [
Identifiants
pubmed: 32249133
pii: S1347-4367(20)30013-6
doi: 10.1016/j.dmpk.2020.01.008
pii:
doi:
Substances chimiques
Monocarboxylic Acid Transporters
0
Creatine
MU72812GK0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
281-287Informations de copyright
Copyright © 2020 The Japanese Society for the Study of Xenobiotics. Published by Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare no conflict of interest.