Architectural proteins for the formation and maintenance of the 3D genome.
3D genome
Hi-C
architectural protein
Journal
Science China. Life sciences
ISSN: 1869-1889
Titre abrégé: Sci China Life Sci
Pays: China
ID NLM: 101529880
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
04
08
2019
accepted:
26
12
2019
pubmed:
7
4
2020
medline:
25
7
2020
entrez:
7
4
2020
Statut:
ppublish
Résumé
Eukaryotic genomes are densely packaged into hierarchical three-dimensional (3D) structures that contain information about gene regulation and many other biological processes. With the development of imaging and sequencing-based technologies, 3D genome studies have revealed that the high-order chromatin structure is composed of hierarchical levels, including chromosome territories, A/B compartments, topologically associated domains, and chromatin loops. However, how this chromatin architecture is formed and maintained is not completely clear. In this review, we introduce experimental methods to investigate the 3D genome, review major architectural proteins that regulate 3D chromatin organization in mammalian cells, such as CTCF (CCCTC-binding factor), cohesin, lamins, and transcription factors, and discuss relevant mechanisms such as phase separation.
Identifiants
pubmed: 32249389
doi: 10.1007/s11427-019-1613-3
pii: 10.1007/s11427-019-1613-3
doi:
Substances chimiques
CCCTC-Binding Factor
0
Cell Cycle Proteins
0
Chromatin
0
Chromosomal Proteins, Non-Histone
0
Lamins
0
Transcription Factors
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
795-810Références
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