Past, present, and future of allergen immunotherapy vaccines.
allergen
allergen-specific immunotherapy
allergy
molecular allergy vaccines
Journal
Allergy
ISSN: 1398-9995
Titre abrégé: Allergy
Pays: Denmark
ID NLM: 7804028
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
03
02
2020
revised:
25
02
2020
accepted:
15
03
2020
pubmed:
7
4
2020
medline:
15
5
2021
entrez:
7
4
2020
Statut:
ppublish
Résumé
Allergen-specific immunotherapy (AIT) is an allergen-specific form of treatment for patients suffering from immunoglobulin E (IgE)-associated allergy; the most common and important immunologically mediated hypersensitivity disease. AIT is based on the administration of the disease-causing allergen with the goal to induce a protective immunity consisting of allergen-specific blocking IgG antibodies and alterations of the cellular immune response so that the patient can tolerate allergen contact. Major advantages of AIT over all other existing treatments for allergy are that AIT induces a long-lasting protection and prevents the progression of disease to severe manifestations. AIT is cost effective because it uses the patient´s own immune system for protection and potentially can be used as a preventive treatment. However, broad application of AIT is limited by mainly technical issues such as the quality of allergen preparations and the risk of inducing side effects which results in extremely cumbersome treatment schedules reducing patient´s compliance. In this article we review progress in AIT made from its beginning and provide an overview of the state of the art, the needs for further development, and possible technical solutions available through molecular allergology. Finally, we consider visions for AIT development towards prophylactic application.
Identifiants
pubmed: 32249442
doi: 10.1111/all.14300
pmc: PMC7818275
doi:
Substances chimiques
Allergens
0
Vaccines
0
Immunoglobulin E
37341-29-0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
131-149Subventions
Organisme : Austrian Science Fund FWF
ID : P 29991
Pays : Austria
Informations de copyright
© 2020 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.
Références
Clin Exp Allergy. 2003 Sep;33(9):1198-208
pubmed: 12956739
World Allergy Organ J. 2019 Oct 24;12(10):100067
pubmed: 31700565
J Immunol. 2014 May 15;192(10):4867-75
pubmed: 24733847
EBioMedicine. 2018 May;31:66-78
pubmed: 29678672
Int Arch Allergy Immunol. 2015;166(1):41-51
pubmed: 25765512
Nat Rev Immunol. 2006 Oct;6(10):761-71
pubmed: 16998509
J Exp Med. 1988 Jan 1;167(1):175-82
pubmed: 3335830
Allergy. 2006 Jul;61(7):855-9
pubmed: 16792584
Allergy. 1985 Jul;40(5):321-35
pubmed: 3898904
Sci Rep. 2017 Sep 14;7(1):11657
pubmed: 28912492
Expert Rev Clin Immunol. 2018 Jan;14(1):61-68
pubmed: 29110542
Proc Natl Acad Sci U S A. 2004 Oct 5;101 Suppl 2:14677-82
pubmed: 15310844
EBioMedicine. 2017 Dec;26:91-99
pubmed: 29221963
Int Arch Allergy Immunol. 1992;97(4):287-94
pubmed: 1597349
JAMA. 2019 Mar 12;321(10):946-955
pubmed: 30794314
J Allergy Clin Immunol. 2001 Aug;108(2):191-7
pubmed: 11496233
J Allergy Clin Immunol. 2016 Jul;138(1):162-8
pubmed: 27373329
Pediatrics. 1968 Nov;42(5):793-802
pubmed: 5685362
Allergy. 2018 Jan;73(1):115-124
pubmed: 28741705
Clin Exp Allergy. 1999 Jul;29(7):896-904
pubmed: 10383589
Hum Vaccin Immunother. 2017 Dec 2;13(12):2804-2813
pubmed: 28605294
Allergy. 2019 Dec;74(12):2461-2478
pubmed: 31228873
J Allergy Clin Immunol. 2011 Feb;127(2):509-516.e1-5
pubmed: 21281875
J Allergy Clin Immunol. 1981 Dec;68(6):460-70
pubmed: 7031112
Pediatr Allergy Immunol. 2014 Dec;25(8):788-95
pubmed: 25406682
J Allergy Clin Immunol. 2019 Sep;144(3):738-749
pubmed: 30844425
Int Arch Allergy Immunol. 2011;154(3):258-63
pubmed: 20861648
Eur J Immunol. 2002 Aug;32(8):2156-62
pubmed: 12209627
J Allergy Clin Immunol. 2012 May;129(5):1290-6
pubmed: 22464647
Allergy. 2014 Oct;69(10):1357-63
pubmed: 24988991
Nat Med. 1996 May;2(5):540-4
pubmed: 8616712
Nat Commun. 2018 Apr 12;9(1):1421
pubmed: 29650949
Curr Allergy Asthma Rep. 2018 Jun 9;18(7):39
pubmed: 29886521
J Allergy Clin Immunol. 2020 Apr;145(4):1153-1156
pubmed: 31678426
Immunol Allergy Clin North Am. 2020 Feb;40(1):69-85
pubmed: 31761122
J Clin Invest. 1997 Apr 1;99(7):1673-81
pubmed: 9120011
Int Arch Allergy Immunol. 2002 Apr;127(4):259-68
pubmed: 12021544
Biotechnology (N Y). 1995 Aug;13(8):779-86
pubmed: 9634808
Lancet. 2019 Jun 1;393(10187):2222-2232
pubmed: 31030987
Allergy. 1986 May;41(4):271-9
pubmed: 3530030
J Allergy Clin Immunol. 2019 Mar;143(3):1226-1229.e10
pubmed: 30414861
Allergy. 2018 Sep;73(9):1842-1850
pubmed: 29512827
J Allergy Clin Immunol. 2017 Dec;140(6):1485-1498
pubmed: 29221580
J Allergy Clin Immunol. 1998 Feb;101(2 Pt 1):258-64
pubmed: 9500760
J Allergy Clin Immunol. 2019 Jul;144(1):61-69.e7
pubmed: 30731124
J Immunol. 1966 Dec;97(6):840-53
pubmed: 4163008
Curr Top Microbiol Immunol. 2011;352:107-19
pubmed: 21567311
J Allergy Clin Immunol. 2020 Jan;145(1):229-238
pubmed: 31525384
Allergy. 2021 Jan;76(1):131-149
pubmed: 32249442
Eur J Immunol. 2020 Jan;50(1):17-32
pubmed: 31799700
Immunochemistry. 1969 Jul;6(4):609-19
pubmed: 4978440
J Allergy Clin Immunol. 1976 Apr;57(4):335-41
pubmed: 57128
Allergy. 2020 Feb;75(2):450-453
pubmed: 31330050
FASEB J. 2002 Mar;16(3):414-6
pubmed: 11790727
J Allergy Clin Immunol. 2019 Mar;143(3):831-843
pubmed: 30850070
Int Arch Allergy Immunol. 2017;173(2):93-98
pubmed: 28654920
J Allergy Clin Immunol. 2015 May;135(5):1207-7.e1-11
pubmed: 25441634
N Engl J Med. 1999 Aug 12;341(7):468-75
pubmed: 10441602
J Biol Chem. 1996 May 3;271(18):10967-72
pubmed: 8631916
Adv Immunol. 2018;138:195-256
pubmed: 29731005
J Allergy Clin Immunol. 2014 Jul;134(1):239-240.e13
pubmed: 24797422
Int Arch Allergy Immunol. 2019;178(2):141-149
pubmed: 30391954
J Immunol. 2007 May 15;178(10):6290-6
pubmed: 17475857
J Immunol. 2013 Apr 1;190(7):3068-78
pubmed: 23440415
J Allergy Clin Immunol. 2019 Aug;144(2):536-548
pubmed: 30685457
Allergy. 2010 Feb;65(2):184-90
pubmed: 19796217
Clin Exp Allergy. 2008 Aug;38(8):1400-8
pubmed: 18564332
J Immunol. 2004 Oct 1;173(7):4433-42
pubmed: 15383574
Curr Opin Allergy Clin Immunol. 2013 Dec;13(6):646-50
pubmed: 24071714
EBioMedicine. 2016 Sep;11:58-67
pubmed: 27568223
Vaccine. 2012 Jun 19;30(29):4328-35
pubmed: 22100888
EMBO J. 1989 Jul;8(7):1935-8
pubmed: 2571499
J Allergy Clin Immunol. 1991 Dec;88(6):889-94
pubmed: 1744359
Immunology. 1967 Oct;13(4):381-94
pubmed: 4168094
J Allergy Clin Immunol. 2008 Nov;122(5):951-60
pubmed: 19000581
N Engl J Med. 2006 Oct 5;355(14):1445-55
pubmed: 17021320
Nature. 1953 Oct 3;172(4379):603-6
pubmed: 13099277
Allergy. 2020 May;75(5):1107-1120
pubmed: 31715001
J Allergy Clin Immunol. 2017 Apr;139(4):1242-1252.e9
pubmed: 28091362
Immunity. 2015 Apr 21;42(4):607-12
pubmed: 25902480
Clin Allergy. 1986 Sep;16(5):483-91
pubmed: 3536171
Pediatr Allergy Immunol. 2018 Nov;29(7):679-688
pubmed: 30063806
Sci Rep. 2019 Mar 8;9(1):4006
pubmed: 30850635
Pediatr Allergy Immunol. 2020 Feb;31 Suppl 24:46-48
pubmed: 32017211
Semin Immunol. 2017 Apr;30:67-80
pubmed: 28939389
J Allergy Clin Immunol. 2020 Apr;145(4):1240-1253.e3
pubmed: 31866435
J Allergy Clin Immunol. 2005 Sep;116(3):608-13
pubmed: 16159631
Proc Natl Acad Sci U S A. 1996 May 14;93(10):5141-5
pubmed: 8643542
Immunol Lett. 2017 Sep;189:19-26
pubmed: 28472641
Allergy. 2018 Feb;73(2):421-430
pubmed: 28791748
Front Immunol. 2017 Dec 22;8:1762
pubmed: 29312303
J Allergy Clin Immunol. 2013 Aug;132(2):353-60.e2
pubmed: 23651609
J Allergy Clin Immunol. 2009 Nov;124(5):997-1002
pubmed: 19733905
Lancet. 2017 May 27;389(10084):2152-2162
pubmed: 28561006
EBioMedicine. 2019 Dec;50:421-432
pubmed: 31786130
J Allergy Clin Immunol. 2013 Sep;132(3):527-535
pubmed: 23993354
J Allergy Clin Immunol. 2000 Jul;106(1 Pt 1):124-34
pubmed: 10887315
J Allergy Clin Immunol. 2006 Jun;117(6):1470-6
pubmed: 16751015
Pediatr Allergy Immunol. 2019 Feb;30(1):59-65
pubmed: 30317676
J Allergy Clin Immunol. 2015 Oct;136(4):1101-3.e8
pubmed: 26048664
J Allergy Clin Immunol. 2018 Aug;142(2):497-509.e9
pubmed: 29361332
Biol Chem. 1999 Jul-Aug;380(7-8):815-24
pubmed: 10494830
Allergy. 1997 Oct;52(10):964-70
pubmed: 9360746
J Immunol. 1998 Mar 15;160(6):2555-9
pubmed: 9510150
J Allergy Clin Immunol. 2019 Mar;143(3):1258-1261
pubmed: 30471304
J Allergy Clin Immunol. 2016 Feb;137(2):351-7
pubmed: 26853127
Allergy. 2016 Aug;71(8):1086-94
pubmed: 26970097
Int Arch Allergy Immunol. 2012;159(3):253-62
pubmed: 22722650
J Allergy Clin Immunol. 2019 Mar;143(3):1218-1221.e4
pubmed: 30389411
Allergy. 2002 May;57(5):423-30
pubmed: 11972482
J Allergy Clin Immunol. 2013 Oct;132(4):991-3.e1
pubmed: 23768574
Allergo J Int. 2018;27(6):162-166
pubmed: 30221123
Nat Rev Immunol. 2007 Feb;7(2):93-104
pubmed: 17259966
Am J Respir Crit Care Med. 1996 Dec;154(6 Pt 1):1623-8
pubmed: 8970345
Allergy. 2015 Jun;70(6):707-10
pubmed: 25704072
J Allergy Clin Immunol. 2018 Feb;141(2):775-777.e6
pubmed: 28506846
Immunol Rev. 2016 May;271(1):246-59
pubmed: 27088919
J Allergy Clin Immunol Pract. 2018 Nov - Dec;6(6):1845-1855.e2
pubmed: 30297269
Ann Allergy Asthma Immunol. 2018 Sep;121(3):313-319
pubmed: 29909054
J Allergy Clin Immunol. 2006 Apr;117(4):802-9
pubmed: 16630937
Proc Natl Acad Sci U S A. 2006 Aug 29;103(35):13144-9
pubmed: 16924110
N Engl J Med. 2015 Feb 26;372(9):803-13
pubmed: 25705822
Lancet. 1998 Feb 28;351(9103):629-32
pubmed: 9500318
J Allergy Clin Immunol. 2011 Jun;127(6):1562-70.e6
pubmed: 21411130
J Allergy Clin Immunol. 2015 Aug;136(2):493-5.e8
pubmed: 25746971
Proc Natl Acad Sci U S A. 1988 Feb;85(3):895-9
pubmed: 3422469
J Allergy Clin Immunol. 2015 Aug;136(2):490-3.e11
pubmed: 25769914
Curr Opin Immunol. 2015 Oct;36:115-26
pubmed: 26386198
J Allergy Clin Immunol. 2017 Feb;139(2):643-654.e6
pubmed: 27464960
J Immunol. 1964 Sep;93:420-5
pubmed: 14218600
FASEB J. 2010 May;24(5):1572-82
pubmed: 20056716
Curr Opin Allergy Clin Immunol. 2019 Dec;19(6):594-605
pubmed: 31464717
Cells. 2019 Aug 28;8(9):
pubmed: 31466324
Clin Allergy. 1984 Nov;14(6):541-50
pubmed: 6391735
Allergy. 2019 Feb;74(2):246-260
pubmed: 30035810
Pediatr Allergy Immunol. 2016 May;27 Suppl 23:1-250
pubmed: 27288833
Eur J Clin Invest. 2009 May;39(5):429-36
pubmed: 19302561
Eur J Pediatr. 2019 Dec;178(12):1801-1812
pubmed: 31414212
J Immunol. 2018 Jun 15;200(12):3897-3904
pubmed: 29728509
Int Arch Allergy Immunol. 2016;170(4):269-278
pubmed: 27780168
World Allergy Organ J. 2013 Oct 03;6(1):17
pubmed: 24090398
Pediatr Allergy Immunol. 2018 Jun;29(4):369-374
pubmed: 29369414
Mol Immunol. 2011 Jan;48(4):431-41
pubmed: 21093057
Clin Exp Allergy. 2012 Aug;42(8):1282-92
pubmed: 22805476
Curr Opin Allergy Clin Immunol. 2019 Aug;19(4):402-414
pubmed: 31082821
EBioMedicine. 2016 Sep;11:43-57
pubmed: 27650868
Allergy. 2018 Feb;73(2):341-349
pubmed: 28787769
Proc Natl Acad Sci U S A. 2008 Nov 18;105(46):17908-12
pubmed: 19001265
J Exp Med. 1935 Nov 30;62(6):733-50
pubmed: 19870445
J Allergy Clin Immunol. 2019 Mar;143(3):1077-1086.e10
pubmed: 30529452
Methods. 2014 Mar 1;66(1):106-19
pubmed: 24161540
Curr Top Microbiol Immunol. 2011;352:161-79
pubmed: 21598105
J Immunol. 2008 Jun 15;180(12):8168-75
pubmed: 18523282
Expert Rev Clin Immunol. 2020 Feb;16(2):167-174
pubmed: 31928251
Nature. 1977 Jun 16;267(5612):618-9
pubmed: 876382
J Immunol. 1996 Jul 15;157(2):956-62
pubmed: 8752951
J Allergy Clin Immunol. 2002 Feb;109(2):251-6
pubmed: 11842293
EBioMedicine. 2016 May;7:230-9
pubmed: 27322476
Lancet. 1954 May 22;266(6821):1055-7
pubmed: 13164324
FASEB J. 2001 Sep;15(11):2045-7
pubmed: 11511511
Int Immunol. 1996 Dec;8(12):1937-45
pubmed: 8982778
J Med Econ. 2018 Jun;21(6):553-555
pubmed: 29295630
J Allergy Clin Immunol. 1998 Oct;102(4 Pt 1):579-91
pubmed: 9802365
Allergy. 2018 Jun;73(6):1254-1262
pubmed: 29322510
Allergy. 2005 May;60(5):678-84
pubmed: 15813815
Int Arch Allergy Immunol. 2020;181(3):170-182
pubmed: 31801149
J Allergy Clin Immunol. 2013 Apr;131(4):1204-12
pubmed: 23453135
Immunol Allergy Clin North Am. 2020 Feb;40(1):175-186
pubmed: 31761117
J Allergy Clin Immunol. 2017 Nov;140(5):1433-1436.e6
pubmed: 28576673
J Allergy Clin Immunol. 2019 Mar;143(3):1248-1252.e12
pubmed: 30445063
J Exp Med. 2009 Aug 31;206(9):1941-55
pubmed: 19667059
Allergy. 2001 Jun;56(6):498-505
pubmed: 11421893
Allergy Asthma Immunol Res. 2016 May;8(3):257-63
pubmed: 26922936
J Allergy Clin Immunol. 1999 Aug;104(2 Pt 1):267-70
pubmed: 10452740
Allergy. 2007 Aug;62(8):943-8
pubmed: 17620073
J Allergy Clin Immunol. 1981 Dec;68(6):449-59
pubmed: 6171586
Allergy. 2020 May;75(5):1232-1236
pubmed: 31701528
J Allergy Clin Immunol. 2012 Jan;129(1):128-35
pubmed: 21996342
J Allergy Clin Immunol. 2017 Feb;139(2):541-549.e8
pubmed: 27793411
J Allergy Clin Immunol. 2019 Jul;144(1):216-223.e3
pubmed: 30879998
Annu Rev Immunol. 2010;28:211-41
pubmed: 20192803
Front Immunol. 2019 Jan 17;9:3131
pubmed: 30705676