Polysaccharide Nanoparticles Bearing HDAC Inhibitor as Nontoxic Nanocarrier for Drug Delivery.
HDAC inhibitor
drug delivery system
nanoparticles
polysaccharides
valproic acid
Journal
Macromolecular bioscience
ISSN: 1616-5195
Titre abrégé: Macromol Biosci
Pays: Germany
ID NLM: 101135941
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
06
02
2020
pubmed:
7
4
2020
medline:
3
6
2021
entrez:
7
4
2020
Statut:
ppublish
Résumé
The histone deacetylase inhibitors (HDACi) are potent drugs in the treatment of inflammatory diseases and defined cancer types. However, major drawbacks of HDACi, such as valproic acid (VPA), are limited serum half-life, side effects and the short circulation time. Thus, the immobilization of VPA in a polysaccharide matrix is used to circumvent these problems and to design a suitable nanocarrier system. Therefore, VPA is covalently attached to cellulose and dextran via esterification with degree of substitution (DS) values of up to 2.20. The resulting hydrophobic polymers are shaped to spherical nanoparticles (NPs) with hydrodynamic diameter between 138 to 221 nm and polydispersity indices from 0.064 to 0.094 by nanoprecipitation and emulsification technique. Lipase treatment of the NPs leads to in vitro release of VPA and hence to an inhibition of HDAC2 activity in a HDAC2 assay. NPs are rapidly taken up by HeLa cells and mainly localize in the cytoplasm. The NPs are hemocompatible and nontoxic as revealed by the shell-less hen's egg model.
Identifiants
pubmed: 32249554
doi: 10.1002/mabi.202000039
doi:
Substances chimiques
Drug Carriers
0
Histone Deacetylase Inhibitors
0
Polysaccharides
0
HDAC2 protein, human
EC 3.5.1.98
Histone Deacetylase 2
EC 3.5.1.98
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2000039Informations de copyright
© 2020 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Références
D. Klemm, B. Heublein, H. P. Fink, A. Bohn, Angew. Chem., Int. Ed. 2005, 44, 3358.
H. Friedman, R. C. Butler, S. Specter, A. Nowotny, Int. J. Immunopharmacol. 1988, 10, 283.
E. A. Generalov, Biophysics 2014, 59, 357.
T. Heinze, O. A. E. Seoud, A. Koschella, Cellulose Derivatives, Springer International, Cham, Switzerland 2018.
H. Wondraczek, K. Petzold-Welcke, P. Fardim, T. Heinze, Cellulose 2013, 20, 751.
N. Anton, J. P. Benoit, P. Saulnier, J. Controlled Release 2008, 128, 185.
S. Hornig, T. Heinze, S. Hesse, T. Liebert, Macromol. Rapid Commun. 2005, 26, 1908.
P. Schulze, M. Gericke, F. Scholz, H. Wondraczek, P. Miethe, T. Heinze, Macromol. Chem. Phys. 2016, 217, 1823.
M. Gericke, P. Schulze, T. Heinze, Macromol. Biosci. 2020, https://doi.org/10.1002/mabi.201900415.
S. K. Nitta, K. Numata, Int. J. Mol. Sci. 2013, 14, 1629.
S. Hornig, H. Bunjes, T. Heinze, J. Colloid Interface Sci. 2009, 338, 56.
S. Daus, T. Heinze, Macromol. Biosci. 2010, 10, 211.
Y. Takakura, A. Takagi, M. Hashida, H. Sezaki, Pharm. Res. 1987, 04, 293.
S. Mizrahy, D. Peer, Chem. Soc. Rev. 2012, 41, 2623.
G. Petzold, K. Petzold-Welcke, H. Qi, K. Stengel, S. Schwarz, T. Heinze, Carbohydr. Polym. 2012, 90, 1712.
Y. Wang, T. Heinze, K. Zhang, Nanoscale 2016, 8, 648.
U.-J. Kim, H. J. Kim, J. W. Choi, S. Kimura, M. Wada, Cellulose 2017, 24, 5517.
H. Zhang, P. Liu, X. Peng, S. Chen, K. Zhang, ACS Sustainable Chem. Eng. 2019, 7, 16595.
E. Verdin, M. Ott, Nat. Rev. Mol. Cell Biol. 2015, 16, 258.
T. Heinzel, O. H. Krämer, Drug Discovery Today: Dis. Mech. 2007, 4, 277.
E. Perucca, CNS Drugs 2002, 16, 695.
M. Göttlicher, S. Minucci, P. Zhu, O. H. Krämer, A. Schimpf, S. Giavara, J. P. Sleeman, F. Lo Coco, C. Nervi, P. G. Pelicci, T. Heinzel, EMBO J. 2001, 20, 6969.
T. Roger, J. Lugrin, D. Le Roy, G. Goy, M. Mombelli, T. Koessler, X. C. Ding, A. L. Chanson, M. K. Reymond, I. Miconnet, J. Schrenzel, P. Francois, T. Calandra, Blood 2011, 117, 1205.
P. R. Powell-Jackson, J. M. Tredger, R. Williams, Gut 1984, 25, 673.
B. Praveen, P. Shrivastava, S. K. Shrivastava, Acta Pharm. Sci. 2009, 51, 169.
T. Heinze, T. Liebert, A. Koschella, Esterification of Polysaccharides, Springer Verlag, Heidelberg, Germany 2006.
C. L. McCormick, T. R. Dawsey, J. K. Newman, Carbohydr. Res. 1990, 208, 183.
M. A. Hussain, T. Liebert, T. Heinze, Polym. News 2004, 29, 14.
S. Blohm, T. Heinze, Starch 2019, 71, 1900053.
C. L. McCormick, T. R. Dawsey, J. K. Newman, Carbohydr. Res. 1990, 208, 183.
S. Hornig, T. Heinze, Biomacromolecules 2008, 9, 1487.
A. A. Kamel, C. M. Ma, M. S. El-Aasser, F. J. Micale, J. W. Vanderhoff, J. Dispersion Sci. Technol. 1981, 2, 315.
H. Q. Woodard, D. R. White, Br. J. Radiol. 1986, 59, 1209.
M. Bauer, C. Lautenschlaeger, K. Kempe, L. Tauhardt, U. S. Schubert, D. Fischer, Macromol. Biosci. 2012, 12, 986.
A. V. Cardoso, M. H. Pereira, G. A. Marcondes, A. R. Ferreira, P. R. Araújo, Mater. Res. 2007, 10, 31.
ASTM F756-13, Standard Practice for Assessment of Hemolytic Properties of Materials, ASTM International, West Conshohocken, PA 2013.
F. Schlenk, S. Werner, M. Rabel, F. Jacobs, C. Bergemann, J. H. Clement, D. Fischer, Arch. Toxicol. 2017, 91, 3271.
V. Hamburger, H. L. Hamilton, Dev. Dyn. 1992, 195, 231.
ICCVAM, National Institute of Environmental Health Sciences National Institutes of Health, ICCVAM test method evaluation report: appendix, 2006.