Efficacy of electrical stimulation of denervated muscle: A multicenter, double-blind, randomized clinical trial.
denervated muscle
electrical stimulation
electromyography
peripheral nerve injuries
recovery of function
rehabilitation
Journal
Muscle & nerve
ISSN: 1097-4598
Titre abrégé: Muscle Nerve
Pays: United States
ID NLM: 7803146
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
03
04
2019
revised:
25
03
2020
accepted:
27
03
2020
pubmed:
7
4
2020
medline:
30
7
2020
entrez:
7
4
2020
Statut:
ppublish
Résumé
This was a multicenter, double-blind, randomized clinical trial to investigate the efficacy of electrical stimulation of denervated muscle (ESDM) on recovery of patients with peripheral nerve injuries. We enrolled 38 patients with traumatic peripheral nerve injuries with axonal damage and clinical impairment of two muscles, who were randomly treated with real or sham electrical stimulation (ES). Clinical and neurophysiological examinations were performed before treatment, at the end of treatment, and 3 mo posttreatment, by the same physician who was blinded to the ES allocation. All patients improved but there was no significant beneficial effect of ESDM compared with sham treatment. This study failed to demonstrate the efficacy of ESDM for peripheral nerve injuries. However, given the large number of variables related to ES and the heterogeneity in disease etiologies and clinical manifestations, future studies on homogeneous populations using different stimulation protocols may be useful.
Sections du résumé
BACKGROUND
This was a multicenter, double-blind, randomized clinical trial to investigate the efficacy of electrical stimulation of denervated muscle (ESDM) on recovery of patients with peripheral nerve injuries.
METHODS
We enrolled 38 patients with traumatic peripheral nerve injuries with axonal damage and clinical impairment of two muscles, who were randomly treated with real or sham electrical stimulation (ES). Clinical and neurophysiological examinations were performed before treatment, at the end of treatment, and 3 mo posttreatment, by the same physician who was blinded to the ES allocation.
RESULTS
All patients improved but there was no significant beneficial effect of ESDM compared with sham treatment.
CONCLUSIONS
This study failed to demonstrate the efficacy of ESDM for peripheral nerve injuries. However, given the large number of variables related to ES and the heterogeneity in disease etiologies and clinical manifestations, future studies on homogeneous populations using different stimulation protocols may be useful.
Types de publication
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
773-778Informations de copyright
© 2020 Wiley Periodicals, Inc.
Références
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