Nicotinamide mononucleotide adenylyltransferase uses its NAD
Alzheimer's disease
D. melanogaster
NAD synthase
NMNAT
biochemistry
chaperone
chemical biology
phosphorylated Tau
tauopathy
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
06 04 2020
06 04 2020
Historique:
received:
13
09
2019
accepted:
21
03
2020
entrez:
7
4
2020
pubmed:
7
4
2020
medline:
30
3
2021
Statut:
epublish
Résumé
Tau hyper-phosphorylation and deposition into neurofibrillary tangles have been found in brains of patients with Alzheimer's disease (AD) and other tauopathies. Molecular chaperones are involved in regulating the pathological aggregation of phosphorylated Tau (pTau) and modulating disease progression. Here, we report that nicotinamide mononucleotide adenylyltransferase (NMNAT), a well-known NAD
Identifiants
pubmed: 32250733
doi: 10.7554/eLife.51859
pii: 51859
pmc: PMC7136026
doi:
pii:
Substances chimiques
HSP90 Heat-Shock Proteins
0
Molecular Chaperones
0
tau Proteins
0
NAD
0U46U6E8UK
Nicotinamide-Nucleotide Adenylyltransferase
EC 2.7.7.1
Banques de données
PDB
['pdb5Z9R', '1NUS']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NCCIH NIH HHS
ID : R61 AT010408
Pays : United States
Organisme : Shanghai Municipal Education Commission
ID : 2019-01-07-00-02-E00037
Organisme : Major State Basic Research Development Program
ID : 2016YFA0501902
Organisme : National Natural Science Foundation of China
ID : 91853113
Organisme : Shanghai Municipal Science and Technology Major Project
ID : 2019SHZDZX02
Organisme : Shanghai Pujiang Program
ID : 18PJ1404300
Organisme : NINDS NIH HHS
ID : R56 NS095893
Pays : United States
Informations de copyright
© 2020, Ma et al.
Déclaration de conflit d'intérêts
XM, YZ, JL, JX, CL, WS, JQ, JL, SD, YX, CW, CJ, HL, JY, YF, LJ, YZ, SZ, RZ, CL, DL No competing interests declared
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