Evaluation of PHITS for microdosimetry in BNCT to support radiobiological research.
Boron neutron capture therapy
Microdosimetry
Monte Carlo simulation
Tissue equivalent proportional counter
Journal
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
ISSN: 1872-9800
Titre abrégé: Appl Radiat Isot
Pays: England
ID NLM: 9306253
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
received:
22
10
2018
revised:
14
11
2019
accepted:
24
03
2020
pubmed:
7
4
2020
medline:
8
7
2021
entrez:
7
4
2020
Statut:
ppublish
Résumé
The aim of this paper is to validate the microdosimetric functionality of the Monte Carlo code, PHITS, and verify its use for estimating dose and RBE for radiobiological studies performed at Kyoto University Institute for Integrated Radiation and Nuclear Science (KURNS). Lineal energy spectra produced by the KUR mixed irradiation mode were measured with a tissue equivalent proportional counter (TEPC) place in free air. The Monte Carlo calculation showed a good agreement with the measured data. In the second part of the study, a realistic set-up of a typical in-vivo radiobiological experiment was simulated with PHITS and the simulation results were compared against TLD and gold foil activation measurements. The Monte Carlo simulation results and the measured data showed an agreement within 3%. The calculated RBE also showed a close value to clinically utilised values. This study shows that PHITS can be utilised to evaluate thermal neutron fluxes and gamma ray absorbed dose rates inside a tumour like medium.
Identifiants
pubmed: 32250844
pii: S0969-8043(18)30941-2
doi: 10.1016/j.apradiso.2020.109148
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
109148Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest None.