Usefulness of monitoring antitumor necrosis factor serum levels during the induction phase in patients with Crohn's disease.
Adalimumab
/ pharmacokinetics
Adult
Anti-Inflammatory Agents
/ pharmacokinetics
Antibodies, Monoclonal
/ blood
Crohn Disease
/ blood
Female
Humans
Induction Chemotherapy
/ methods
Infliximab
/ pharmacokinetics
Male
Necrosis
Prospective Studies
Remission Induction
Treatment Outcome
Tumor Necrosis Factor-alpha
/ antagonists & inhibitors
Journal
European journal of gastroenterology & hepatology
ISSN: 1473-5687
Titre abrégé: Eur J Gastroenterol Hepatol
Pays: England
ID NLM: 9000874
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
entrez:
7
4
2020
pubmed:
7
4
2020
medline:
29
6
2021
Statut:
ppublish
Résumé
The aims of this study were (a) to know the kinetics of antitumor necrosis factor (TNF) drug serum levels during the induction phase in patients with Crohn's disease; (b) to identify variables associated with these levels; and (c) to assess the relation between these levels and short-term effectiveness in Crohn's disease patients. Patients with Crohn's disease naïve to anti-TNF treatment were prospectively included. Remission was defined as a Crohn's disease activity index (CDAI) score <150 after 14 weeks of treatment. Blood samples were obtained at baseline and at weeks 4, 8, and 14. Adalimumab and infliximab levels were measured, receiver operating characteristic (ROC) curves were constructed, and the area under the ROC curve was calculated. One-hundred fifty patients with Crohn's disease were included, 79 (53%) received infliximab and 71 (47%) had CDAI > 150 at study entry. At week 14, 52 out of 71 patients with CDAI > 150 at baseline (73%) had clinical remission. There were no differences in infliximab levels between patients with and without remission (8 vs. 9.1 μg/mL, P > 0.05) or with and without response (7 vs. 11 μg/mL, P > 0.05) at week 14. There was a trend to higher levels of adalimumab concentration in responders in comparison with nonresponders (13 vs. 6.7 μg/mL, P = 0.05) and in patients who achieved remission in comparison with nonremitters (13.5 vs. 8.4 μg/mL, P = 0.06). In the multivariate analysis, no variable was predictive of short-term remission, including infliximab and adalimumab serum levels. Determining anti-TNF serum levels during the induction phase is not useful for predicting short-term remission in patients with Crohn's disease.
Identifiants
pubmed: 32251204
doi: 10.1097/MEG.0000000000001706
pii: 00042737-202005000-00008
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Antibodies, Monoclonal
0
Tumor Necrosis Factor-alpha
0
Infliximab
B72HH48FLU
Adalimumab
FYS6T7F842
Types de publication
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
588-596Références
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