Ultrastructural characterization of mitochondrial damage in experimental autoimmune neuritis.
Axon
Mitochondria
Neuritis
Neuroinflammation
Schwann cell
Journal
Journal of neuroimmunology
ISSN: 1872-8421
Titre abrégé: J Neuroimmunol
Pays: Netherlands
ID NLM: 8109498
Informations de publication
Date de publication:
15 06 2020
15 06 2020
Historique:
received:
05
03
2020
revised:
16
03
2020
accepted:
18
03
2020
pubmed:
7
4
2020
medline:
11
11
2020
entrez:
7
4
2020
Statut:
ppublish
Résumé
Data are sparse about mitochondrial damage in GBS and in its most frequently employed animal model, experimental autoimmune neuritis (EAN). We here characterized changes in mitochondrial content and morphology at different time points during EAN by use of ultrastructural imaging and immunofluorescent labelling. Histological examination revealed that demyelinated axons and their adjacent Schwann cells showed reduced mitochondrial content and remaining mitochondria appeared swollen with greater diameter in Schwann cells and unmyelinated axons. Our findings indicate that in EAN, particularly mitochondria in Schwann cells are damaged. Further studies are warranted to address whether these changes are amenable to novel, mitoprotective treatments.
Identifiants
pubmed: 32251941
pii: S0165-5728(20)30139-9
doi: 10.1016/j.jneuroim.2020.577218
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
577218Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors report that they do not have any financial or other conflicts of interest related to this study.