Similar Microglial Cell Densities across Brain Structures and Mammalian Species: Implications for Brain Tissue Function.
cell density
cell numbers
comparative
evolution
microglia
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
10 06 2020
10 06 2020
Historique:
received:
29
09
2019
revised:
10
12
2019
accepted:
05
01
2020
pubmed:
8
4
2020
medline:
30
10
2020
entrez:
8
4
2020
Statut:
ppublish
Résumé
Microglial cells play essential volume-related actions in the brain that contribute to the maturation and plasticity of neural circuits that ultimately shape behavior. Microglia can thus be expected to have similar cell sizes and even distribution both across brain structures and across species with different brain sizes. To test this hypothesis, we determined microglial cell densities (the inverse of cell size) using immunocytochemistry to Iba1 in samples of free cell nuclei prepared with the isotropic fractionator from brain structures of 33 mammalian species belonging to males and females of five different clades. We found that microglial cells constitute ∼7% of non-neuronal cells in different brain structures as well as in the whole brain of all mammalian species examined. Further, they vary little in cell density compared with neuronal cell densities within the cerebral cortex, across brain structures, across species within the same clade, and across mammalian clades. As a consequence, we find that one microglial cell services as few as one and as many as 100 neurons in different brain regions and species, depending on the local neuronal density. We thus conclude that the addition of microglial cells to mammalian brains is governed by mechanisms that constrain the size of these cells and have remained conserved over 200 million years of mammalian evolution. We discuss the probable consequences of such constrained size for brain function in health and disease.
Identifiants
pubmed: 32253358
pii: JNEUROSCI.2339-19.2020
doi: 10.1523/JNEUROSCI.2339-19.2020
pmc: PMC7294795
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4622-4643Subventions
Organisme : NICHD NIH HHS
ID : P50 HD103537
Pays : United States
Informations de copyright
Copyright © 2020 the authors.
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