Surface carboxylation or PEGylation decreases CuO nanoparticles' cytotoxicity to human cells in vitro without compromising their antibacterial properties.
Antibacterial
Immunotoxicity
Nanomedicine
Nanosafety
Particle internalization
Surface coating
Journal
Archives of toxicology
ISSN: 1432-0738
Titre abrégé: Arch Toxicol
Pays: Germany
ID NLM: 0417615
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
31
01
2020
accepted:
26
03
2020
pubmed:
8
4
2020
medline:
23
4
2021
entrez:
8
4
2020
Statut:
ppublish
Résumé
Clinical use of CuO nanoparticles (NPs) as antibacterials can be hampered by their toxicity to human cells. We hypothesized that certain surface functionalizations of CuO NPs may render NPs toxic to bacteria, but still be relatively harmless to human cells. To control this hypothesis, the toxicity of differently functionalized CuO NPs to bacteria Escherichia coli vs human cells (THP-1 macrophages and HACAT keratinocytes) was compared using similar conditions and end points. CuO NPs functionalized with polyethylene glycol (CuO-PEG), carboxyl (CuO-COOH, anionic), ammonium (CuO-NH
Identifiants
pubmed: 32253467
doi: 10.1007/s00204-020-02720-7
pii: 10.1007/s00204-020-02720-7
pmc: PMC7261733
doi:
Substances chimiques
Anti-Bacterial Agents
0
Reactive Oxygen Species
0
Copper
789U1901C5
cupric oxide
V1XJQ704R4
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1561-1573Références
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