Ameliorative effects of Magnolia sieboldii buds hexane extract on experimental reflux esophagitis.
Magonolia sieboldii
NF-κB signaling pathway
anti-inflammatory effects
cytokines
esophageal damage
reflux esophagitis
Journal
Phytotherapy research : PTR
ISSN: 1099-1573
Titre abrégé: Phytother Res
Pays: England
ID NLM: 8904486
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
19
01
2020
revised:
15
03
2020
accepted:
17
03
2020
pubmed:
8
4
2020
medline:
29
10
2020
entrez:
8
4
2020
Statut:
ppublish
Résumé
Gastroesophageal reflux disease (GERD) is a disease that stomach contents continually refluxing into esophagus causes symptoms and/or complications. The study was working to find natural plant extracts with good effects and small side effects to treat reflux esophagitis (RE). The anti-inflammatory effects of hexane extract of Magnolia sieboldii (MsHE) were conducted on lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells. The ameliorative effects of MsHE on esophageal damage in rats induced by gastric acid reflux was explored in vivo. The results showed that MsHE decreased the production of nitric oxide (NO) and expression levels of iNOS, COX-2 and TNF-α on LPS-stimulated RAW 264.7 cells and MsHE treatment ameliorated the rats' esophageal tissue damage induced by gastric acid and inhibited the increase of inflammatory mediators and pro-inflammatory cytokines by regulating NF-κB signaling pathway. In addition, MsHE protected the function of barrier of epithelial cells against inflammatory conditions through increasing the expression of tight junctions. Furthermore, liquid chromatography-mass spectrometry analysis was used for determine the active ingredients contained in MsHE. The results show that MsHE can alleviate experimental rat RE by regulating NF-κB signaling pathway. In summary, MsHE may be used as a source material of drug candidate for the treatment of RE.
Substances chimiques
Hexanes
0
Plant Extracts
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2385-2396Subventions
Organisme : National Research Foundation of Korea
ID : NRF-2017-R1D1A3B03036020
Informations de copyright
© 2020 John Wiley & Sons, Ltd.
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