Bacterial toxins in musculoskeletal infections.
PJI
Staphylococcus
bacterial toxins
biofilm meeting
musculoskeletal infection (MSKI)
virulence factors
Journal
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
ISSN: 1554-527X
Titre abrégé: J Orthop Res
Pays: United States
ID NLM: 8404726
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
20
11
2019
revised:
27
02
2020
accepted:
01
04
2020
pubmed:
8
4
2020
medline:
1
5
2021
entrez:
8
4
2020
Statut:
ppublish
Résumé
Musculoskeletal infections (MSKIs) remain a major health burden in orthopaedics. Bacterial toxins are foundational to pathogenesis in MSKI, but poorly understood by the community of providers that care for patients with MSKI, inducing an international group of microbiologists, infectious diseases specialists, orthopaedic surgeons and biofilm scientists to review the literature in this field to identify key topics and compile the current knowledge on the role of toxins in MSKI, with the goal of illuminating potential impact on biofilm formation and dispersal as well as therapeutic strategies. The group concluded that further research is needed to maximize our understanding of the effect of toxins on MSKIs, including: (i) further research to identify the roles of bacterial toxins in MSKIs, (ii) establish the understanding of the importance of environmental and host factors and in vivo expression of toxins throughout the course of an infection, (iii) establish the principles of drug-ability of antitoxins as antimicrobial agents in MSKIs, (iv) have well-defined metrics of success for antitoxins as antiinfective drugs, (v) design a cocktail of antitoxins against specific pathogens to (a) inhibit biofilm formation and (b) inhibit toxin release. The applicability of antitoxins as potential antimicrobials in the era of rising antibiotic resistance could meet the needs of day-to-day clinicians.
Identifiants
pubmed: 32255540
doi: 10.1002/jor.24683
pmc: PMC7541548
mid: NIHMS1591420
doi:
Substances chimiques
Bacterial Toxins
0
Types de publication
Consensus Development Conference
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
240-250Subventions
Organisme : NIAMS NIH HHS
ID : P50 AR072000
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR069119
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR072513
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM124436
Pays : United States
Informations de copyright
© 2020 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.
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