Total Glycosides of
Cistanche deserticola
Nrf-2/Keap-1 pathway
cerebral injury
oligosaccharides
polysaccharides
total glycosides
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2020
2020
Historique:
received:
25
07
2019
accepted:
20
02
2020
entrez:
8
4
2020
pubmed:
8
4
2020
medline:
8
4
2020
Statut:
epublish
Résumé
The traditional Chinese medicine We investigated the brain protective effects of extracts from TGs treatment remarkably decreased neurological deficit scores and infarction volumes, promoted angiogenesis and neural remodeling, and effectively maintained blood-brain-barrier integrity compared with the model group. Furthermore, TGs significantly decreased MDA levels and increased antioxidant activities (SOD, CAT, and GSH-Px) in brains. Meanwhile, TGs remarkably downregulated Keap-1 expression and facilitated Nrf-2 nuclear translocation. On the contrary, no protective effects were observed for PSs and OSs groups. TGs are the main active components of
Sections du résumé
BACKGROUND
BACKGROUND
The traditional Chinese medicine
METHODS
METHODS
We investigated the brain protective effects of extracts from
RESULTS
RESULTS
TGs treatment remarkably decreased neurological deficit scores and infarction volumes, promoted angiogenesis and neural remodeling, and effectively maintained blood-brain-barrier integrity compared with the model group. Furthermore, TGs significantly decreased MDA levels and increased antioxidant activities (SOD, CAT, and GSH-Px) in brains. Meanwhile, TGs remarkably downregulated Keap-1 expression and facilitated Nrf-2 nuclear translocation. On the contrary, no protective effects were observed for PSs and OSs groups.
CONCLUSION
CONCLUSIONS
TGs are the main active components of
Identifiants
pubmed: 32256351
doi: 10.3389/fphar.2020.00236
pmc: PMC7089931
doi:
Types de publication
Journal Article
Langues
eng
Pagination
236Informations de copyright
Copyright © 2020 Wang, Li, Tu, Chen, Zeng and Jiang.
Références
Eur J Pharmacol. 2013 May 5;707(1-3):26-31
pubmed: 23541723
Drug Des Devel Ther. 2016 Jan 14;10:315-25
pubmed: 26834461
Stroke. 2013 Jun;44(6):1690-7
pubmed: 23632977
Mol Biol Rep. 2019 Feb;46(1):241-250
pubmed: 30406889
Eur Respir J. 2016 Mar;47(3):876-88
pubmed: 26699726
J Physiol Sci. 2018 Mar;68(2):121-127
pubmed: 28078626
Oxid Med Cell Longev. 2017;2017:7150376
pubmed: 28690765
Trends Neurosci. 2000 Jun;23(6):265-71
pubmed: 10838596
Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):E3910-8
pubmed: 24062466
J Neurosci. 1997 Jun 1;17(11):4180-9
pubmed: 9151735
Evid Based Complement Alternat Med. 2015;2015:103985
pubmed: 26435722
Biol Pharm Bull. 2018;41(11):1645-1651
pubmed: 30381663
Nature. 2010 Nov 25;468(7323):557-61
pubmed: 20944627
Mol Neurobiol. 2010 Jun;41(2-3):172-9
pubmed: 20157789
Mol Neurobiol. 2017 Oct;54(8):6006-6017
pubmed: 27696223
Neurotherapeutics. 2011 Jul;8(3):319-29
pubmed: 21691873
Basic Clin Pharmacol Toxicol. 2019 Jun;124(6):660-669
pubmed: 30548093
Stroke. 2006 Jun;37(6):1533-8
pubmed: 16627788
Continuum (Minneap Minn). 2017 Feb;23(1, Cerebrovascular Disease):15-39
pubmed: 28157742
Ann Vasc Surg. 2016 Jul;34:234-42
pubmed: 27129809
Prog Neurobiol. 2018 Apr - May;163-164:144-171
pubmed: 28987927
Neural Regen Res. 2016 Mar;11(3):368-71
pubmed: 27127459
Neuron. 2010 Nov 4;68(3):409-27
pubmed: 21040844
Int J Mol Sci. 2016 Aug 29;17(9):
pubmed: 27589720
Curr Neurovasc Res. 2017;14(1):71-81
pubmed: 27897111
Microcirculation. 2019 Oct;26(7):e12575
pubmed: 31132190
Lancet. 2008 May 10;371(9624):1612-23
pubmed: 18468545
Evid Based Complement Alternat Med. 2017;2017:3925903
pubmed: 28744316
Fluids Barriers CNS. 2016 Oct 11;13(1):16
pubmed: 27724968
J Chromatogr A. 2009 Mar 13;1216(11):1970-9
pubmed: 18691718
PLoS Biol. 2010 Jun 29;8(6):e1000412
pubmed: 20613859
Am J Transl Res. 2015 Jun 15;7(6):976-94
pubmed: 26279744
Oxid Med Cell Longev. 2018 Nov 18;2018:6069150
pubmed: 30581534
Free Radic Biol Med. 2015 Nov;88(Pt B):93-100
pubmed: 26117331
Evid Based Complement Alternat Med. 2015;2015:134685
pubmed: 26681963
Stroke. 2014 Mar;45(3):912-3
pubmed: 24526060
PLoS One. 2018 Jan 23;13(1):e0191356
pubmed: 29360858
Pharmacol Ther. 2015 Feb;146:23-34
pubmed: 25196155
Front Cell Neurosci. 2016 Sep 02;10:213
pubmed: 27642277
Ann Neurol. 2007 Aug;62(2):170-6
pubmed: 17683090
Phytochemistry. 2018 Sep;153:36-47
pubmed: 29860140
Chin Med J (Engl). 2019 Jun 5;132(11):1344-1353
pubmed: 30939485
Int J Mol Sci. 2018 Oct 09;19(10):
pubmed: 30304824
Cell Death Dis. 2019 May 1;10(5):360
pubmed: 31043581
BMC Complement Altern Med. 2017 Sep 26;17(1):470
pubmed: 28950851
Chin Med. 2007 Mar 27;2:3
pubmed: 17386115
J Bioenerg Biomembr. 2015 Apr;47(1-2):101-10
pubmed: 25262285
Neurochem Res. 2018 Feb;43(2):420-429
pubmed: 29168092
Molecules. 2018 Oct 26;23(11):
pubmed: 30373188
Carbohydr Res. 2007 Jul 23;342(10):1343-9
pubmed: 17442280
Mol Neurobiol. 2015 Dec;52(3):1430-1439
pubmed: 25452227
Chem Pharm Bull (Tokyo). 2016 Jul 1;64(7):1024-30
pubmed: 27063326
Phytochemistry. 2019 Aug;164:111-121
pubmed: 31125861
Neural Regen Res. 2016 Jun;11(6):914-5
pubmed: 27482215
Gend Med. 2012 Apr;9(2):121-8
pubmed: 22445684
Am J Physiol Heart Circ Physiol. 2016 Jun 1;310(11):H1702-14
pubmed: 27059078
Exp Ther Med. 2019 May;17(5):3755-3767
pubmed: 30988761
Neurochem Int. 2019 Jun;126:96-108
pubmed: 30880045
Br J Pharmacol. 2010 Aug;160(7):1573-6
pubmed: 20649560
Int J Mol Sci. 2016 Jun 24;17(7):
pubmed: 27347934
J Vis Exp. 2015 May 07;(99):e52699
pubmed: 25992584
Sci Rep. 2014 Nov 11;4:7002
pubmed: 25384416
Biosci Biotechnol Biochem. 2019 Dec;83(12):2202-2212
pubmed: 31409200
Int J Mol Sci. 2018 Apr 10;19(4):
pubmed: 29642608
Neuroscientist. 2014 Feb;20(1):56-70
pubmed: 23774218
J Clin Invest. 2015 Apr;125(4):1433-45
pubmed: 25798616
Brain Res. 2014 Jan 28;1544:45-53
pubmed: 24316243
J Neurol Sci. 2012 Feb 15;313(1-2):142-6
pubmed: 21945462
J Toxicol Environ Health A. 2005 Mar 12;68(5):389-400
pubmed: 15799629
Br J Pharmacol. 2014 Jul;171(13):3146-57
pubmed: 24611741
Acta Pharmacol Sin. 2018 Jun;39(6):998-1011
pubmed: 29022576
J Neurochem. 2001 Sep;78(6):1389-99
pubmed: 11579147
Nature. 2010 Nov 25;468(7323):562-6
pubmed: 20944625
Am J Chin Med. 2012;40(6):1123-41
pubmed: 23227786
Chin J Integr Med. 2018 Apr;24(4):243-246
pubmed: 29696521
J Cell Biochem. 2019 Sep;120(9):15891-15905
pubmed: 31144355
Proc Natl Acad Sci U S A. 2006 Jan 17;103(3):768-73
pubmed: 16407140
Redox Rep. 2007;12(1):11-5
pubmed: 17263901
Neurobiol Dis. 2016 Jul;91:262-73
pubmed: 26996728