Gamma Oryzanol Alleviates High-Fat Diet-Induced Anxiety-Like Behaviors Through Downregulation of Dopamine and Inflammation in the Amygdala of Mice.
amygdala
anxiety
dopamine
high-fat diet
γ-oryzanol
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2020
2020
Historique:
received:
26
08
2019
accepted:
06
03
2020
entrez:
8
4
2020
pubmed:
8
4
2020
medline:
8
4
2020
Statut:
epublish
Résumé
A high-fat diet (HFD) can induce obesity and metabolic disorders that are closely associated with cognitive impairments, and the progression of several psychiatric disorders such as anxiety. We have previously demonstrated the anxiolytic-like effect of Gamma oryzanol (GORZ) in chronic restraint stressed mice. We studied the neurochemical and molecular mechanisms that underlie the preventive effect of GORZ in HFD-induced anxiety-like behaviors, monoaminergic dysfunction, and inflammation. Eight-week-old Institute of Cancer (ICR) male mice weighing 33-34 g were divided into the following groups and free-fed for 8 weeks: control (14% casein, AIN 93M); HFD; HFD + GORZ (0.5% GORZ). Body weight gain was checked weekly. The anxiolytic-like effects of GORZ were examined Mice fed a HFD for eight weeks showed anxiety-like behaviors in association with HFD-induced body weight gain. GORZ potentially blocked HFD-induced anxiety-like behaviors Our findings strongly suggest that 0.5% GORZ exerts anxiolytic-like effects, possibly through downregulation of dopamine, and
Sections du résumé
BACKGROUND
BACKGROUND
A high-fat diet (HFD) can induce obesity and metabolic disorders that are closely associated with cognitive impairments, and the progression of several psychiatric disorders such as anxiety. We have previously demonstrated the anxiolytic-like effect of Gamma oryzanol (GORZ) in chronic restraint stressed mice.
OBJECTIVE
OBJECTIVE
We studied the neurochemical and molecular mechanisms that underlie the preventive effect of GORZ in HFD-induced anxiety-like behaviors, monoaminergic dysfunction, and inflammation.
METHODS
METHODS
Eight-week-old Institute of Cancer (ICR) male mice weighing 33-34 g were divided into the following groups and free-fed for 8 weeks: control (14% casein, AIN 93M); HFD; HFD + GORZ (0.5% GORZ). Body weight gain was checked weekly. The anxiolytic-like effects of GORZ were examined
RESULTS
RESULTS
Mice fed a HFD for eight weeks showed anxiety-like behaviors in association with HFD-induced body weight gain. GORZ potentially blocked HFD-induced anxiety-like behaviors
CONCLUSIONS
CONCLUSIONS
Our findings strongly suggest that 0.5% GORZ exerts anxiolytic-like effects, possibly through downregulation of dopamine, and
Identifiants
pubmed: 32256371
doi: 10.3389/fphar.2020.00330
pmc: PMC7090127
doi:
Types de publication
Journal Article
Langues
eng
Pagination
330Informations de copyright
Copyright © 2020 Akter, Uddin, Sasaki and Shibata.
Références
Brain Res. 2012 Aug 27;1470:24-34
pubmed: 22765913
Diabetologia. 2006 Sep;49(9):2109-19
pubmed: 16783472
Lipids. 2016 Apr;51(4):451-67
pubmed: 26939679
Pharmacol Rev. 2011 Mar;63(1):182-217
pubmed: 21303898
Physiol Behav. 2008 Jun 9;94(3):309-15
pubmed: 18325546
Obes Res Clin Pract. 2013 May-Jun;7(3):e165-72
pubmed: 23697584
Mol Cell Endocrinol. 2009 Feb 27;299(2):163-71
pubmed: 19084046
Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15324-9
pubmed: 21876127
Psychoneuroendocrinology. 2013 Nov;38(11):2562-74
pubmed: 23850224
Physiol Rev. 1998 Jan;78(1):189-225
pubmed: 9457173
J Comp Neurol. 2004 Aug 23;476(3):301-11
pubmed: 15269972
Psychosom Med. 2008 Apr;70(3):288-97
pubmed: 18378873
Neuroscience. 2004;123(2):429-40
pubmed: 14698750
Chronic Dis Can. 2009;30(1):29-36
pubmed: 20031086
Brain Behav. 2017 Apr 20;7(6):e00708
pubmed: 28638713
Sci Rep. 2012;2:431
pubmed: 22666534
J Neurosci. 2014 Feb 12;34(7):2618-31
pubmed: 24523551
Int J Endocrinol. 2013;2013:701967
pubmed: 24027581
Neuropsychopharmacology. 2012 Jan;37(1):137-62
pubmed: 21918508
Neurotoxicology. 2015 Dec;51:96-105
pubmed: 26366809
J Clin Biochem Nutr. 2010 Mar;46(2):150-6
pubmed: 20216948
Mol Nutr Food Res. 2012 Jun;56(6):935-44
pubmed: 22707268
Nature. 2011 Mar 17;471(7338):358-62
pubmed: 21389985
Life Sci. 2019 Jan 1;216:119-128
pubmed: 30468832
J Clin Invest. 2012 Jan;122(1):153-62
pubmed: 22201683
Nutrients. 2019 Jan 06;11(1):
pubmed: 30621350
Endocrinology. 2005 Oct;146(10):4192-9
pubmed: 16002529
Diabetes Care. 2001 Jun;24(6):1069-78
pubmed: 11375373
Nucleic Acids Res. 2012 Aug;40(15):e115
pubmed: 22730293
Endocrinology. 2015 Apr;156(4):1242-50
pubmed: 25594697
Front Cell Neurosci. 2013 Dec 19;7:260
pubmed: 24391541
Behav Brain Res. 2008 Aug 5;191(1):130-6
pubmed: 18453006
Diabetes. 2012 Dec;61(12):3084-93
pubmed: 22826028
Science. 1993 Jan 1;259(5091):87-91
pubmed: 7678183
eNeuro. 2017 Jun 1;4(3):
pubmed: 28580417
Behav Neurosci. 2008 Dec;122(6):1257-63
pubmed: 19045945
Int J Obes (Lond). 2013 Mar;37(3):382-9
pubmed: 22508336
Psychopharmacology (Berl). 2015 Dec;232(24):4393-400
pubmed: 26359228
Food Sci Nutr. 2014 Mar;2(2):75-104
pubmed: 24804068
Arch Gen Psychiatry. 2009 Dec;66(12):1361-72
pubmed: 19996041
J Agric Food Chem. 2012 Apr 4;60(13):3367-72
pubmed: 22401580
Phytomedicine. 2008 Nov;15(11):951-8
pubmed: 18424018
Neuropsychopharmacology. 2016 Jun;41(7):1874-87
pubmed: 26658303
Springerplus. 2013 Apr 16;2(1):165
pubmed: 23667814
Life Sci. 2007 Jun 27;81(3):198-203
pubmed: 17574275
Curr Top Med Chem. 2011;11(14):1847-53
pubmed: 21506933
J Clin Invest. 2006 Jun;116(6):1494-505
pubmed: 16691291
Am J Physiol Endocrinol Metab. 2009 May;296(5):E1003-12
pubmed: 19116375
Proc Natl Acad Sci U S A. 2015 Dec 22;112(51):15731-6
pubmed: 26644559
Psychoneuroendocrinology. 2011 Jun;36(5):623-33
pubmed: 20888697
Sci Rep. 2015 Jun 15;5:11417
pubmed: 26073568
J Agric Food Chem. 1999 Jul;47(7):2724-8
pubmed: 10552553
Bioinformatics. 2007 May 15;23(10):1289-91
pubmed: 17379693
BMC Med. 2015 Sep 08;13:215
pubmed: 26349802
Diabetologia. 2017 Aug;60(8):1502-1511
pubmed: 28528402