The Effects of Mechanical Preload on Transmural Differences in Mechano-Calcium-Electric Feedback in Single Cardiomyocytes: Experiments and Mathematical Models.
electromechanical coupling
length-dependent activation
mechanical preload
mechano-calcium-electric feedback
single cardiomyocytes
transmural differences
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2020
2020
Historique:
received:
30
11
2019
accepted:
13
02
2020
entrez:
8
4
2020
pubmed:
8
4
2020
medline:
8
4
2020
Statut:
epublish
Résumé
Transmural differences in ventricular myocardium are maintained by electromechanical coupling and mechano-calcium/mechano-electric feedback. In the present study, we experimentally investigated the influence of preload on the force characteristics of subendocardial (Endo) and subepicardial (Epi) single ventricular cardiomyocytes stretched by up to 20% from slack sarcomere length (SL) and analyzed the results with the help of mathematical modeling. Mathematical models of Endo and Epi cells, which accounted for regional heterogeneity in ionic currents, Ca
Identifiants
pubmed: 32256377
doi: 10.3389/fphys.2020.00171
pmc: PMC7091561
doi:
Types de publication
Journal Article
Langues
eng
Pagination
171Informations de copyright
Copyright © 2020 Khokhlova, Konovalov, Iribe, Solovyova and Katsnelson.
Références
Heart Rhythm. 2007 Mar;4(3):341-8
pubmed: 17341400
J Mol Cell Cardiol. 2018 Jan;114:276-287
pubmed: 29217431
J Physiol. 2002 Jun 15;541(Pt 3):863-75
pubmed: 12068046
Proc Natl Acad Sci U S A. 2016 Dec 20;113(51):14852-14857
pubmed: 27930302
Circ Res. 2017 Aug 18;121(5):537-548
pubmed: 28637782
Am J Physiol Heart Circ Physiol. 2000 Nov;279(5):H2568-73
pubmed: 11045995
J Cell Physiol. 2018 Aug;233(8):6273-6279
pubmed: 29528120
Am J Physiol. 1987 Jul;253(1 Pt 1):C90-6
pubmed: 2955701
J Mol Cell Cardiol. 1997 Jun;29(6):1629-37
pubmed: 9220348
Mol Biol Rep. 2012 Apr;39(4):3847-52
pubmed: 21750914
Cardiovasc Res. 2004 Aug 1;63(2):283-92
pubmed: 15249186
J Physiol Sci. 2018 Jul;68(4):387-413
pubmed: 28573594
J Physiol. 2010 Aug 1;588(Pt 15):2891-903
pubmed: 20530113
J Theor Biol. 2004 Oct 7;230(3):385-405
pubmed: 15302547
Circ Res. 1985 Jul;57(1):152-63
pubmed: 4006099
J Mol Cell Cardiol. 2005 Sep;39(3):419-28
pubmed: 16026799
Front Physiol. 2018 Aug 09;9:1077
pubmed: 30140239
J Physiol. 2006 Feb 15;571(Pt 1):131-46
pubmed: 16357014
Pflugers Arch. 2008 Oct;457(1):25-36
pubmed: 18449562
Circ Res. 2006 May 26;98(10):1306-13
pubmed: 16614306
J Physiol. 2006 Apr 1;572(Pt 1):227-41
pubmed: 16423856
Bull Math Biol. 2008 Apr;70(3):910-49
pubmed: 18259823
J Biomed Biotechnol. 2011;2011:310791
pubmed: 22162634
Am J Physiol Heart Circ Physiol. 2007 Mar;292(3):H1487-97
pubmed: 17098830
Biophys J. 2004 Dec;87(6):3723-36
pubmed: 15465866
Acta Physiol (Oxf). 2013 May;208(1):95-110
pubmed: 23356774
Biophys J. 2001 Dec;81(6):3029-51
pubmed: 11720973
J Physiol. 2004 Aug 15;559(Pt 1):103-20
pubmed: 15194740
PLoS One. 2013 May 09;8(5):e63141
pubmed: 23671664
Circulation. 1989 Mar;79(3):712-7
pubmed: 2917394
Prog Biophys Mol Biol. 2016 Jan;120(1-3):249-54
pubmed: 26713555
J Physiol. 2008 Nov 1;586(21):5203-14
pubmed: 18787035
Pflugers Arch. 2011 Jul;462(1):89-104
pubmed: 21499986
J Mol Cell Cardiol. 2011 Apr;50(4):731-9
pubmed: 21255582
J Physiol. 2019 Feb;597(3):711-722
pubmed: 30315728
Am J Physiol Heart Circ Physiol. 2004 Jul;287(1):H196-202
pubmed: 15001443
J Physiol. 2003 Nov 15;553(Pt 1):147-54
pubmed: 12963792
J Gen Physiol. 2016 Jan;147(1):53-62
pubmed: 26712849
J Mol Cell Cardiol. 2000 May;32(5):735-44
pubmed: 10775479
Circulation. 2011 May 3;123(17):1881-90
pubmed: 21502574
FASEB J. 2005 Jan;19(1):88-90
pubmed: 15498894
Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):2306-11
pubmed: 26858417
PLoS One. 2017 Sep 1;12(9):e0183671
pubmed: 28863155
J Physiol. 2003 Mar 15;547(Pt 3):825-33
pubmed: 12562927
Circ Arrhythm Electrophysiol. 2018 Jan;11(1):e005914
pubmed: 29311162
J Am Coll Cardiol. 2007 Feb 27;49(8):909-16
pubmed: 17320750
J Mol Cell Cardiol. 2011 Sep;51(3):428-34
pubmed: 21708170
PLoS One. 2015 Jul 21;10(7):e0133274
pubmed: 26196737
Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2155-60
pubmed: 21460195
Prog Biophys Mol Biol. 2014 Aug;115(2-3):103-14
pubmed: 24976617
Am J Physiol Heart Circ Physiol. 2010 Dec;299(6):H1812-22
pubmed: 20889843
Cardiovasc Res. 2015 Oct 1;108(1):188-96
pubmed: 26209251
Am J Physiol Heart Circ Physiol. 2004 Apr;286(4):H1471-9
pubmed: 14670817
Circ Res. 1995 Jul;77(1):199-205
pubmed: 7788878
Cardiovasc Res. 2006 Sep 1;71(4):652-60
pubmed: 16860293
Cardiovasc Res. 2001 Jun;50(3):454-62
pubmed: 11376621
Am J Physiol Heart Circ Physiol. 2010 Aug;299(2):H454-69
pubmed: 20525874
Biophys J. 2019 Oct 1;117(7):1258-1268
pubmed: 31537313
Pflugers Arch. 2011 Jul;462(1):39-48
pubmed: 21494804