The Broad Concept of "Spasticity-Plus Syndrome" in Multiple Sclerosis: A Possible New Concept in the Management of Multiple Sclerosis Symptoms.

multiple sclerosis spasticity symptom cluster symptomatic therapy symptomatic treatment

Journal

Frontiers in neurology
ISSN: 1664-2295
Titre abrégé: Front Neurol
Pays: Switzerland
ID NLM: 101546899

Informations de publication

Date de publication:
2020
Historique:
received: 22 08 2019
accepted: 14 02 2020
entrez: 8 4 2020
pubmed: 8 4 2020
medline: 8 4 2020
Statut: epublish

Résumé

Multiple sclerosis (MS) pathology progressively affects multiple central nervous system (CNS) areas. Due to this fact, MS produces a wide array of symptoms. Symptomatic therapy of one MS symptom can cause or worsen other unwanted symptoms (anticholinergics used for bladder dysfunction produce impairment of cognition, many MS drugs produce erectile dysfunction, etc.). Appropriate symptomatic therapy is an unmet need. Several important functions/symptoms (muscle tone, sleep, bladder, pain) are mediated, in great part, in the brainstem. Cannabinoid receptors are distributed throughout the CNS irregularly: There is an accumulation of CB

Identifiants

pubmed: 32256440
doi: 10.3389/fneur.2020.00152
pmc: PMC7090019
doi:

Types de publication

Journal Article

Langues

eng

Pagination

152

Informations de copyright

Copyright © 2020 Fernández, Costa-Frossard, Martínez-Ginés, Montero, Prieto and Ramió.

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Auteurs

Óscar Fernández (Ó)

Biomedical Research Institute of Malaga, University of Málaga, Málaga, Spain.

Lucienne Costa-Frossard (L)

Department of Neurology, Ramón y Cajal University Hospital, Madrid, Spain.

Marisa Martínez-Ginés (M)

Department of Neurology, Gregorio Marañón Hospital, Madrid, Spain.

Paloma Montero (P)

Servicio de Neurología, Hospital Clínico San Carlos, Madrid, Spain.

José Maria Prieto (JM)

Servicio de Neurologia, Complejo Hospitalario Universitario de Santiago, Santiago de Compostela, Spain.

Lluis Ramió (L)

Servicio de Neurologia, Hospital Universitari de Girona Doctor Josep Trueta, Girona, Spain.

Classifications MeSH