Influenza-Induced Interferon Lambda Response Is Associated With Longer Time to Delivery Among Pregnant Kenyan Women.


Journal

Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960

Informations de publication

Date de publication:
2020
Historique:
received: 18 12 2019
accepted: 27 02 2020
entrez: 8 4 2020
pubmed: 8 4 2020
medline: 5 3 2021
Statut: epublish

Résumé

Specific causes of preterm birth remain unclear. Several recent studies have suggested that immune changes during pregnancy are associated with the timing of delivery, yet few studies have been performed in low-income country settings where the rates of preterm birth are the highest. We conducted a retrospective nested case-control evaluation within a longitudinal study among HIV-uninfected pregnant Kenyan women. To characterize immune function in these women, we evaluated unstimulated and stimulated peripheral blood mononuclear cells

Identifiants

pubmed: 32256497
doi: 10.3389/fimmu.2020.00452
pmc: PMC7089959
doi:

Substances chimiques

interferon-lambda, human 0
interferon-lambda, human 0
interferon-lambda, human 0
Interleukins 0
Interferons 9008-11-1

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

452

Subventions

Organisme : NIDA NIH HHS
ID : DP1 DA046089
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD094718
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI131302
Pays : United States
Organisme : NICHD NIH HHS
ID : F31 HD089675
Pays : United States
Organisme : NICHD NIH HHS
ID : P01 HD064915
Pays : United States

Informations de copyright

Copyright © 2020 Seiler, Bayless, Vergara, Pintye, Kinuthia, Osborn, Matemo, Richardson, John-Stewart, Holmes and Blish.

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Auteurs

Christof Seiler (C)

Department of Statistics, Stanford University, Stanford, CA, United States.
Department of Data Science and Knowledge Engineering, Maastricht University, Maastricht, Netherlands.

Nicholas L Bayless (NL)

Immunology Program, Stanford University School of Medicine, Stanford, CA, United States.

Rosemary Vergara (R)

Department of Medicine, Stanford University School of Medicine, Stanford, CA, United States.

Jillian Pintye (J)

Department of Global Health, University of Washington School of Medicine, Seattle, WA, United States.

John Kinuthia (J)

Kenyatta National Hospital, Nairobi, Kenya.

Lusi Osborn (L)

Kenyatta National Hospital, Nairobi, Kenya.

Daniel Matemo (D)

Kenyatta National Hospital, Nairobi, Kenya.

Barbra A Richardson (BA)

Department of Global Health, University of Washington School of Medicine, Seattle, WA, United States.
Department of Biostatistics, University of Washington, Seattle, WA, United States.

Grace John-Stewart (G)

Department of Global Health, University of Washington School of Medicine, Seattle, WA, United States.

Susan Holmes (S)

Department of Statistics, Stanford University, Stanford, CA, United States.

Catherine A Blish (CA)

Immunology Program, Stanford University School of Medicine, Stanford, CA, United States.
Department of Medicine, Stanford University School of Medicine, Stanford, CA, United States.
Chan Zuckerberg Biohub, San Francisco, CA, United States.

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