Deworming children for soil-transmitted helminths in low and middle-income countries: systematic review and individual participant data network meta-analysis.
Deworming
individual participant data
network meta-analysis
systematic review
Journal
Journal of development effectiveness
ISSN: 1943-9342
Titre abrégé: J Dev Effect
Pays: England
ID NLM: 101530325
Informations de publication
Date de publication:
2019
2019
Historique:
received:
07
11
2019
accepted:
07
11
2019
entrez:
8
4
2020
pubmed:
8
4
2020
medline:
8
4
2020
Statut:
epublish
Résumé
Intestinal parasites affect millions of children globally. We aimed to assess effects of deworming children on nutritional and cognitive outcomes across potential effect modifiers using individual participant data (IPD). We searched multiple databases to 27 March 2018, grey literature, and other sources. We included randomised and quasi randomised trials of deworming compared to placebo or other nutritional interventions with data on baseline infection. We used a random-effects network meta-analysis with IPD and assessed overall quality, following a pre-specified protocol. We received IPD from 19 trials of STH deworming. Overall risk of bias was low. There were no statistically significant subgroup effects across age, sex, nutritional status or infection intensity for each type of STH. These analyses showed that children with moderate or heavy intensity infections, deworming for STH may increase weight gain (very low certainty). The added value of this review is an exploration of effects on growth and cognition in children with moderate to heavy infections as well as replicating prior systematic review results of small effects at the population level. Policy implications are that complementary public health strategies need to be assessed and considered to achieve growth and cognition benefits for children in helminth endemic areas.
Identifiants
pubmed: 32256965
doi: 10.1080/19439342.2019.1691627
pii: 1691627
pmc: PMC7077355
doi:
Types de publication
Journal Article
Langues
eng
Pagination
288-306Subventions
Organisme : Medical Research Council
ID : MC_UU_00027/5
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R010161/1
Pays : United Kingdom
Informations de copyright
© 2019 Informa UK Limited, trading as Taylor & Francis Group.
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