hPCL3S promotes proliferation and migration of androgen-independent prostate cancer cells.
PHF19
PRC2
hPCL3S
prostate cancer
β-catenin
Journal
Oncotarget
ISSN: 1949-2553
Titre abrégé: Oncotarget
Pays: United States
ID NLM: 101532965
Informations de publication
Date de publication:
24 Mar 2020
24 Mar 2020
Historique:
received:
19
09
2019
accepted:
17
02
2020
entrez:
8
4
2020
pubmed:
8
4
2020
medline:
8
4
2020
Statut:
epublish
Résumé
Polycomb repressive complex 2 (PRC2) allows the deposition of H3K27me3. PRC2 facultative subunits modulate its activity and recruitment such as hPCL3/PHF19, a human ortholog of Drosophila Polycomb-like protein (PCL). These proteins contain a TUDOR domain binding H3K36me3, two PHD domains and a "Winged-helix" domain involved in GC-rich DNA binding. The human PCL3 locus encodes the full-length hPCL3L protein and a shorter isoform, hPCL3S containing the TUDOR and PHD1 domains only. In this study, we demonstrated by RT-qPCR analyses of 25 prostate tumors that hPCL3S is frequently up-regulated. In addition, hPCL3S is overexpressed in the androgen-independent DU145 and PC3 cells, but not in the androgen-dependent LNCaP cells.
Identifiants
pubmed: 32256978
doi: 10.18632/oncotarget.27511
pii: 27511
pmc: PMC7105160
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1051-1074Déclaration de conflit d'intérêts
CONFLICTS OF INTEREST The authors declare no disclosure of potential conflicts of interest.
Références
Nature. 2018 Sep;561(7721):127-131
pubmed: 30150773
Mol Cancer. 2010 Mar 10;9:55
pubmed: 20219091
Tumour Biol. 2016 Sep;37(9):12241-12250
pubmed: 27240591
Nat Protoc. 2009;4(1):44-57
pubmed: 19131956
Trends Biochem Sci. 2011 Jul;36(7):364-72
pubmed: 21514168
Genome Biol. 2014;15(12):550
pubmed: 25516281
Cell. 2017 Sep 21;171(1):163-178.e19
pubmed: 28844694
Nature. 2011 Jan 20;469(7330):343-9
pubmed: 21248841
J Mol Med (Berl). 2005 Dec;83(12):1014-24
pubmed: 16211407
Bioessays. 2016 May;38(5):446-54
pubmed: 27000413
Prostate. 2000 Feb 15;42(3):186-95
pubmed: 10639189
Nat Commun. 2019 Jan 17;10(1):278
pubmed: 30655535
Clin Cancer Res. 2017 May 1;23(9):2245-2254
pubmed: 27799248
Nature. 2017 Sep 14;549(7671):287-291
pubmed: 28869966
Oncotarget. 2016 Mar 22;7(12):14220-40
pubmed: 26871947
Nat Rev Genet. 2019 Oct;20(10):599-614
pubmed: 31267064
Bioinformatics. 2014 Apr 1;30(7):923-30
pubmed: 24227677
Proc Natl Acad Sci U S A. 2019 Oct 29;116(44):22189-22195
pubmed: 31611391
Cell Cycle. 2016;15(3):305-6
pubmed: 26652297
Nat Rev Mol Cell Biol. 2017 Jan;18(1):18-30
pubmed: 27677860
Blood. 2019 Oct 3;134(14):1176-1189
pubmed: 31383640
Prostate. 2011 Nov;71(15):1668-79
pubmed: 21432867
Oncogene. 2014 Apr 24;33(17):2204-14
pubmed: 23708657
J Biol Chem. 2012 Mar 23;287(13):10509-24
pubmed: 22315224
Am J Transl Res. 2015 Feb 15;7(2):175-93
pubmed: 25901190
Front Oncol. 2014 Mar 25;4:60
pubmed: 24724054
Genes Dev. 2018 Sep 1;32(17-18):1105-1140
pubmed: 30181359
Nat Rev Cancer. 2016 Dec;16(12):803-810
pubmed: 27658528
Nat Struct Mol Biol. 2012 Dec;19(12):1273-81
pubmed: 23160351
Mol Cell. 2018 Mar 1;69(5):840-852.e5
pubmed: 29499137
Genes Dev. 2015 Nov 1;29(21):2231-43
pubmed: 26494712
Cell. 2017 Sep 21;171(1):34-57
pubmed: 28938122
Nucleic Acids Res. 2009 Jan;37(1):1-13
pubmed: 19033363
Cancer Res. 2003 Nov 1;63(21):7056-61
pubmed: 14612495
Bioinformatics. 2013 Jan 1;29(1):15-21
pubmed: 23104886
J Biol Chem. 2013 Apr 12;288(15):10254-64
pubmed: 23417673
Nat Struct Mol Biol. 2012 Dec;19(12):1257-65
pubmed: 23104054
J Biol Chem. 2001 Nov 16;276(46):43065-73
pubmed: 11571280
FEBS J. 2015 May;282(9):1723-35
pubmed: 25271128
Cell Stem Cell. 2012 May 4;10(5):556-69
pubmed: 22560078
Cell Death Dis. 2018 Oct 15;9(11):1049
pubmed: 30323224
Cancer Res. 2018 May 15;78(10):2536-2549
pubmed: 29483096
Nat Genet. 2018 Jul;50(7):1002-1010
pubmed: 29808031
Mol Cell. 2013 Feb 7;49(3):571-82
pubmed: 23273982
J Biol Chem. 2006 Dec 15;281(50):38905-17
pubmed: 17030513
Trends Biochem Sci. 2006 Jan;31(1):35-40
pubmed: 16297627
Hum Mol Genet. 2003 Feb 15;12(4):441-50
pubmed: 12566391
Oncotarget. 2016 Mar 8;7(10):11018-32
pubmed: 26783961
Mol Cancer Res. 2011 Jul;9(7):914-24
pubmed: 21669963
Trends Biochem Sci. 2017 Jul;42(7):531-542
pubmed: 28483375
Bioinformatics. 2010 Mar 15;26(6):841-2
pubmed: 20110278
Biochem J. 2011 Mar 1;434(2):333-42
pubmed: 21143197
Trends Biochem Sci. 1995 Feb;20(2):56-9
pubmed: 7701562
Mol Cell. 2011 Sep 16;43(6):853-66
pubmed: 21925375
Gene. 2004 Dec 8;343(1):69-78
pubmed: 15563832
Trends Cell Biol. 2019 Aug;29(8):660-671
pubmed: 31178244
PLoS Genet. 2012;8(3):e1002576
pubmed: 22438827