Brain atrophy in multiple sclerosis: mechanisms, clinical relevance and treatment options.
Atrophy
Axon
Bran
Drugs
Inflammation
Multiple sclerosis
Neurodegeneration
Neuroprotection
Journal
Auto- immunity highlights
ISSN: 2038-0305
Titre abrégé: Auto Immun Highlights
Pays: England
ID NLM: 101532391
Informations de publication
Date de publication:
Dec 2019
Dec 2019
Historique:
received:
13
03
2019
accepted:
28
06
2019
entrez:
8
4
2020
pubmed:
8
4
2020
medline:
8
4
2020
Statut:
epublish
Résumé
Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system characterized by focal or diffuse inflammation, demyelination, axonal loss and neurodegeneration. Brain atrophy can be seen in the earliest stages of MS, progresses faster compared to healthy adults, and is a reliable predictor of future physical and cognitive disability. In addition, it is widely accepted to be a valid, sensitive and reproducible measure of neurodegeneration in MS. Reducing the rate of brain atrophy has only recently been incorporated as a critical endpoint into the clinical trials of new or emerging disease modifying drugs (DMDs) in MS. With the advent of easily accessible neuroimaging softwares along with the accumulating evidence, clinicians may be able to use brain atrophy measures in their everyday clinical practice to monitor disease course and response to DMDs. In this review, we will describe the different mechanisms contributing to brain atrophy, their clinical relevance on disease presentation and course and the effect of current or emergent DMDs on brain atrophy and neuroprotection.
Identifiants
pubmed: 32257063
doi: 10.1186/s13317-019-0117-5
pii: 117
pmc: PMC7065319
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
7Informations de copyright
© The Author(s) 2019.
Déclaration de conflit d'intérêts
Competing interestsThe authors declare that they have no competing interests.
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