Factors associated with multi-drug-resistant tuberculosis in Dakar, Senegal, 2010-2016.
Dakar
factors
multidrug-resistant tuberculosis
Journal
Journal of public health in Africa
ISSN: 2038-9922
Titre abrégé: J Public Health Afr
Pays: Italy
ID NLM: 101586943
Informations de publication
Date de publication:
31 Dec 2019
31 Dec 2019
Historique:
received:
22
04
2019
accepted:
17
10
2019
entrez:
8
4
2020
pubmed:
8
4
2020
medline:
8
4
2020
Statut:
epublish
Résumé
According to the World Health Organization, multidrug-resistant tuberculosis (MDR-TB) represents a major obstacle towards successful TB treatment and control. In Dakar, MDR-TB management began in 2010 with the strengthening of diagnostic resources. The objective of this study was to identify the factors associated with multidrug-resistant tuberculosis in Dakar between 2010 and 2016. We conducted a case-control study from January 10 to February 28, 2017 in tuberculosis centers in Dakar. of 169 cases and 507 controls. We used logistic regression with Epi-info version 7.2.1. to estimate the odds ratios of association. Factors significantly associated with MDR-TB were: residing in a periurban area (ORa=1.8; 95% CI (1.5-4.9); p=0.024), presence of MDR-TB in the entourage of patient (ORa=7.0; 95% CI (6.1-9.5); p=0.002), previous treatment failure (ORa=29.5; 95% CI (27.3-30.1); p=0.000), treatment not directly observed by a health care provider (ORa=4.3; 95% CI (4.1-7,2); p=0.000) and irregularity of treatment (ORa=1.7; 95% CI (0.5-5.4); p=0.037). Focusing interventions on population at-risk will prevent MDR-TB.
Identifiants
pubmed: 32257080
doi: 10.4081/jphia.2019.1099
pmc: PMC7118427
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1099Informations de copyright
©Copyright: the Author(s), 2019.
Déclaration de conflit d'intérêts
Conflict of interest: The authors declare no conflict of interest.
Références
Transbound Emerg Dis. 2019 Jul;66(4):1611-1618
pubmed: 30924283
BMC Res Notes. 2012 Aug 28;5:462
pubmed: 22929063
Int J Tuberc Lung Dis. 2017 Jul 1;21(7):774-777
pubmed: 28633701
APMIS. 2012 Jun;120(6):503-9
pubmed: 22583363
Int J Mycobacteriol. 2012 Sep;1(3):137-42
pubmed: 26787209
Afr Health Sci. 2015 Jun;15(2):368-77
pubmed: 26124781
Int J Tuberc Lung Dis. 2010 Apr;14(4):382-90
pubmed: 20202293
Int J Prev Med. 2019 May 17;10:67
pubmed: 31198502
Int J Infect Dis. 2015 Oct;39:57-61
pubmed: 26327121
Pan Afr Med J. 2016 Apr 06;23:157
pubmed: 27516818
Thorax. 2006 Feb;61(2):158-63
pubmed: 16254056
Int J Infect Dis. 2008 Nov;12(6):635-44
pubmed: 18514008