Coombs-positive Paroxysmal Nocturnal Haemoglobinuria.
Autoimmune haemolytic anaemia
Direct antiglobulin test
Eculizumab
Glycosylphosphatidylinositol
PIGA
Paroxysmal Nocturnal Haemoglobinuria
Journal
Oxford medical case reports
ISSN: 2053-8855
Titre abrégé: Oxf Med Case Reports
Pays: England
ID NLM: 101642070
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
received:
24
08
2017
revised:
22
04
2018
accepted:
27
10
2019
entrez:
8
4
2020
pubmed:
8
4
2020
medline:
8
4
2020
Statut:
epublish
Résumé
Autoimmune haemolytic anaemia (AIHA) and paroxysmal nocturnal haemoglobinuria (PNH) are two distinct causes of haemolytic anaemia. They have different mechanisms that underpin their pathogenesis and, therefore, require different treatment strategies. The direct antiglobulin test (DAT) or Coombs test is positive in cases of immune-mediated haemolytic anaemia and, thus, is positive in AIHA but negative in PNH. We report a case of a woman presenting with a haemolytic anaemia who was found to have concomitant evidence of AIHA and PNH. The case highlights the importance of carrying out a comprehensive haemolysis work-up in patients who present with haemolytic anaemia.
Identifiants
pubmed: 32257252
doi: 10.1093/omcr/omz125
pii: omz125
pmc: PMC7104188
doi:
Types de publication
Case Reports
Langues
eng
Pagination
omz125Informations de copyright
© The Author(s) 2020. Published by Oxford University Press.
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