COVID-19 infection: Origin, transmission, and characteristics of human coronaviruses.
COVID-19
Coronaviruses
Origin
Outbreak
Spread
Journal
Journal of advanced research
ISSN: 2090-1232
Titre abrégé: J Adv Res
Pays: Egypt
ID NLM: 101546952
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
received:
15
03
2020
accepted:
15
03
2020
entrez:
8
4
2020
pubmed:
8
4
2020
medline:
8
4
2020
Statut:
epublish
Résumé
The coronavirus disease 19 (COVID-19) is a highly transmittable and pathogenic viral infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which emerged in Wuhan, China and spread around the world. Genomic analysis revealed that SARS-CoV-2 is phylogenetically related to severe acute respiratory syndrome-like (SARS-like) bat viruses, therefore bats could be the possible primary reservoir. The intermediate source of origin and transfer to humans is not known, however, the rapid human to human transfer has been confirmed widely. There is no clinically approved antiviral drug or vaccine available to be used against COVID-19. However, few broad-spectrum antiviral drugs have been evaluated against COVID-19 in clinical trials, resulted in clinical recovery. In the current review, we summarize and comparatively analyze the emergence and pathogenicity of COVID-19 infection and previous human coronaviruses severe acute respiratory syndrome coronavirus (SARS-CoV) and middle east respiratory syndrome coronavirus (MERS-CoV). We also discuss the approaches for developing effective vaccines and therapeutic combinations to cope with this viral outbreak.
Identifiants
pubmed: 32257431
doi: 10.1016/j.jare.2020.03.005
pii: S2090-1232(20)30054-0
pmc: PMC7113610
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
91-98Informations de copyright
© 2020 THE AUTHORS. Published by Elsevier BV on behalf of Cairo University.
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