Association of TERT, OGG1, and CHRNA5 Polymorphisms and the Predisposition to Lung Cancer in Eastern Algeria.
Journal
Pulmonary medicine
ISSN: 2090-1844
Titre abrégé: Pulm Med
Pays: Egypt
ID NLM: 101558762
Informations de publication
Date de publication:
2020
2020
Historique:
received:
22
12
2019
revised:
01
02
2020
accepted:
03
03
2020
entrez:
8
4
2020
pubmed:
8
4
2020
medline:
6
7
2021
Statut:
epublish
Résumé
Lung cancer remains the most common cancer in the world. The genetic polymorphisms (rs2853669 in TERT, rs1052133 in OGG1, and rs16969968 in CHRNA5 genes) were shown to be strongly associated with the risk of lung cancer. Our study's aim is to elucidate whether these polymorphisms predispose Eastern Algerian population to non-small-cell lung cancer (NSCLC). To date, no study has considered this association in the Algerian population. This study included 211 healthy individuals and 144 NSCLC cases. Genotyping was performed using TaqMan probes and Sanger sequencing, and the data were analyzed using multivariate logistic regression adjusted for covariates. The minor allele frequencies (MAFs) of TERT rs2853669, CHRNA5 rs16969968, and OGG1 rs1052133 polymorphisms in controls were C: 20%, A: 31%, and G: 29%, respectively. Of the three polymorphisms, none shows a significant association, but stratified analysis rs16969968 showed that persons carrying the AA genotype are significantly associated with adenocarcinoma risk (pAdj = 0.03, ORAdj = 2.55). Smokers with an AA allele have a larger risk of lung cancer than smokers with GG or GA genotype (pAdj = 0.03, ORAdj = 3.91), which is not the case of nonsmokers. Our study suggests that CHRNA5 rs16969968 polymorphism is associated with a significant increase of lung adenocarcinoma risk and with a nicotinic addiction.
Identifiants
pubmed: 32257438
doi: 10.1155/2020/7649038
pmc: PMC7109590
doi:
Substances chimiques
CHRNA5 protein, human
0
Nerve Tissue Proteins
0
Receptors, Nicotinic
0
TERT protein, human
EC 2.7.7.49
Telomerase
EC 2.7.7.49
DNA Glycosylases
EC 3.2.2.-
oxoguanine glycosylase 1, human
EC 3.2.2.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
7649038Informations de copyright
Copyright © 2020 Asma Mimouni et al.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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