The Liver That Cured Christmas: Case Report of Orthotopic Liver Transplant in a Patient with Hemophilia B.
Journal
Case reports in transplantation
ISSN: 2090-6943
Titre abrégé: Case Rep Transplant
Pays: United States
ID NLM: 101591863
Informations de publication
Date de publication:
2020
2020
Historique:
received:
11
11
2019
accepted:
06
01
2020
entrez:
8
4
2020
pubmed:
8
4
2020
medline:
8
4
2020
Statut:
epublish
Résumé
Herein, we discuss a case of a 39-year-old male with hemophilia B, who developed end-stage liver disease secondary to nonalcoholic steatohepatitis, that underwent orthotopic liver transplantation (OLT) as a curative means for his liver disease and coagulation disorder. Existing case reports have demonstrated favorable outcomes in patients outside of the United States who received continuous infusions of recombinant factor IX replacement in the perioperative setting after liver transplant. Given limitations in the stability of the recombinant factor IX products in the United States, a dosing strategy was comprised of once daily bolus dosing to achieve satisfactory factor IX levels. Within 48 hours of initial surgery, the patient had sustained factor IX levels above 70% of normal and the patient required no further dosing of factor IX products to date. This strategy helped facilitate less frequent dosing as well as achieved targeted factor levels while synthetic function of the transplanted liver recovered.
Identifiants
pubmed: 32257502
doi: 10.1155/2020/7873803
pmc: PMC7104118
doi:
Types de publication
Case Reports
Langues
eng
Pagination
7873803Informations de copyright
Copyright © 2020 Jesse E. Harris et al.
Déclaration de conflit d'intérêts
No study collaborators have any conflicts of interest to disclose.
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