Comparison of toxic responses to acetaminophen challenge in ICR mice originating from different sources.
Acetaminophen
GSH
Hepatotoxicity
ICR mouse
Journal
Laboratory animal research
ISSN: 1738-6055
Titre abrégé: Lab Anim Res
Pays: England
ID NLM: 101560684
Informations de publication
Date de publication:
2019
2019
Historique:
received:
21
05
2019
accepted:
22
08
2019
entrez:
8
4
2020
pubmed:
8
4
2020
medline:
8
4
2020
Statut:
epublish
Résumé
Acetaminophen (APAP) is the most common antipyretic analgesic worldwide. However, APAP overdose causes severe liver injury, especially centrilobular necrosis, in humans and experimental animals. At therapeutic dosage, APAP is mainly metabolized by sulfation and glucuronidation, and partly by cytochrome P450-mediated oxidation. However, APAP overdose results in production of excess reactive metabolite, N-acetyl-
Identifiants
pubmed: 32257904
doi: 10.1186/s42826-019-0017-x
pii: 17
pmc: PMC7081583
doi:
Types de publication
Journal Article
Langues
eng
Pagination
16Informations de copyright
© The Author(s) 2019.
Déclaration de conflit d'intérêts
Competing interestsThe authors declare that they have no competing interests.
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