Novel Therapeutic Strategies for Ovarian Cancer Stem Cells.
Auger electron and alpha particle emitters
L1CAM
cancer stem cells
epithelial-to-mesenchymal transition
ovarian cancer
radioimmunotherapy
therapeutic strategies
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2020
2020
Historique:
received:
30
09
2019
accepted:
21
02
2020
entrez:
8
4
2020
pubmed:
8
4
2020
medline:
8
4
2020
Statut:
epublish
Résumé
Ovarian cancer (OC) is one of the most lethal gynecologic malignancies. Due to the lack of specific symptoms and screening methods, this disease is usually diagnosed only at an advanced and metastatic stage. The gold-standard treatment for OC patients consists of debulking surgery followed by taxane combined with platinum-based chemotherapy. Most patients show complete clinical remission after first-line therapy, but the majority of them ultimately relapse, developing radio- and chemoresistant tumors. It is now proposed that the cause of recurrence and reduced therapy efficacy is the presence of small populations of cancer stem cells (CSCs). These cells are usually resistant against conventional cancer therapies and for this reason, effective targeted therapies for the complete eradication of CSCs are urgently needed. In this review article, we highlight the mechanisms of CSC therapy resistance, epithelial-to-mesenchymal transition, stemness, and novel therapeutic strategies for ovarian CSCs.
Identifiants
pubmed: 32257947
doi: 10.3389/fonc.2020.00319
pmc: PMC7090172
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
319Informations de copyright
Copyright © 2020 Terraneo, Jacob, Dubrovska and Grünberg.
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