Metabolic correlates of prevalent mild cognitive impairment and Alzheimer's disease in adults with Down syndrome.
Alzheimer's disease
Down syndrome
carbohydrate metabolism
energy metabolism
fatty acid metabolism
lipid metabolism
metabolism
metabolomics
mild cognitive impairment
Journal
Alzheimer's & dementia (Amsterdam, Netherlands)
ISSN: 2352-8729
Titre abrégé: Alzheimers Dement (Amst)
Pays: United States
ID NLM: 101654604
Informations de publication
Date de publication:
2020
2020
Historique:
received:
09
01
2020
revised:
14
02
2020
accepted:
19
02
2020
entrez:
8
4
2020
pubmed:
8
4
2020
medline:
8
4
2020
Statut:
epublish
Résumé
Disruption of metabolic function is a recognized feature of late onset Alzheimer's disease (LOAD). We sought to determine whether similar metabolic pathways are implicated in adults with Down syndrome (DS) who have increased risk for Alzheimer's disease (AD). We examined peripheral blood from 292 participants with DS who completed baseline assessments in the Alzheimer's Biomarkers Consortium-Down Syndrome (ABC-DS) using untargeted mass spectrometry (MS). Our sample included 38 individuals who met consensus criteria for AD (DS-AD), 43 who met criteria for mild cognitive impairment (DS-MCI), and 211 who were cognitively unaffected and stable (CS). We measured relative abundance of 8,805 features using MS and 180 putative metabolites were differentially expressed (DE) among the groups at false discovery rate-corrected Our results reveal metabolic alterations in DS-AD that are similar to those seen in LOAD. The pattern of results in this cross-sectional DS cohort suggests a dynamic time course of metabolic dysregulation which evolves with clinical progression from non-demented, to MCI, to AD. Metabolomic markers may be useful for staging progression of DS-AD.
Identifiants
pubmed: 32258359
doi: 10.1002/dad2.12028
pii: DAD212028
pmc: PMC7131985
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e12028Subventions
Organisme : NIA NIH HHS
ID : P30 AG062715
Pays : United States
Organisme : NIA NIH HHS
ID : U24 AG021886
Pays : United States
Informations de copyright
© 2020 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, Inc. on behalf of the Alzheimer's Association.
Déclaration de conflit d'intérêts
MM and AKC are listed as inventors on issued and pending patents related to material in this manuscript and assigned to Georgetown University. The terms of this arrangement have been reviewed and approved by the University of California, Irvine in accordance with its conflict of interest policies. Remaining authors declare no competing financial interests.
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