Temperature-dependent formulation of a hydrogel based on Hyaluronic acid-polydimethylsiloxane for biomedical applications.
Biocompatibility
Hyaluronic acid
Hydrogels
Long-term stability
Materials science
Polydimethylsiloxane-diglycidyl ether terminated
Viscoelastic behavior
Journal
Heliyon
ISSN: 2405-8440
Titre abrégé: Heliyon
Pays: England
ID NLM: 101672560
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
received:
27
11
2019
revised:
04
02
2020
accepted:
24
02
2020
entrez:
8
4
2020
pubmed:
8
4
2020
medline:
8
4
2020
Statut:
epublish
Résumé
Hyaluronic acid (HA), as a safe biomaterial with minimal immunogenicity, is being employed in a broad range of medical applications. Since unmodified HA has a high potential for biodegradation in the physiological condition, herein, an HA-based cross-linked hydrogel was formulated using polydimethylsiloxane-diglycidyl ether terminated (PDMS-DG) via epoxide-OH reaction. The formation of HA-PDMS hydrogel was confirmed using FTIR, NMR, and FESEM. Temperature demonstrated a critical role in the physicochemical properties of the final products. Gel-37, which formed at 37 °C, had a higher modification degree (MD) and more stability against hyaluronidase and oxidative stress than the hydrogel formulated at 25 °C (Gel-25). In addition, the swelling ratio, roughness, and porous network topology of Gel-25 and Gel-37 were different. The rheology measurement indicated that HA-PDMS hydrogel had a stable viscoelastic character. The hydrogel was also biocompatible, non-cytotoxic, and considerably stable during 7-months storage. Overall, various determined parameters confirmed that HA-PDMS hydrogel is worth using in different medical applications. Keywords: Hyaluronic acid; Polydimethylsiloxane-diglycidyl ether terminated; Hydrogels; Long-term stability; Viscoelastic behavior; Biocompatibility.
Identifiants
pubmed: 32258450
doi: 10.1016/j.heliyon.2020.e03494
pii: S2405-8440(20)30339-X
pii: e03494
pmc: PMC7096762
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e03494Informations de copyright
© 2020 Published by Elsevier Ltd.
Références
Biomaterials. 1997 Feb;18(3):189-95
pubmed: 9031718
J Drugs Dermatol. 2012 Nov;11(11):1336-41
pubmed: 23135085
J Biomed Mater Res. 1999 Nov;47(2):152-69
pubmed: 10449626
Pathol Biol (Paris). 2010 Jun;58(3):187-98
pubmed: 19932571
Nanoscale. 2018 May 17;10(19):9174-9185
pubmed: 29725687
Exp Physiol. 1991 Jan;76(1):125-34
pubmed: 2015069
J Control Release. 2005 Jan 20;102(1):13-22
pubmed: 15653130
Nat Protoc. 2006;1(4):2128-36
pubmed: 17487204
Colloids Surf B Biointerfaces. 2016 Apr 1;140:392-402
pubmed: 26780252
Clin Interv Aging. 2008;3(1):153-9
pubmed: 18488885
Biomaterials. 2013 Jul;34(21):5273-80
pubmed: 23591396
Med Sci Monit. 2011 Apr;17(4):BR91-6
pubmed: 21455101
Biotechnol Lett. 2007 Jan;29(1):17-25
pubmed: 17091377
Patient Prefer Adherence. 2009 Nov 03;3:225-30
pubmed: 19936165
Acta Biomater. 2013 Jul;9(7):7081-92
pubmed: 23507088
J Biomed Mater Res. 1997 Nov;37(2):243-51
pubmed: 9358318
Clin Interv Aging. 2007;2(3):369-76
pubmed: 18044187
Carbohydr Polym. 2016 Nov 5;152:632-638
pubmed: 27516313
Int J Pharm. 2016 Sep 10;511(1):380-389
pubmed: 27436707
Eur J Pharm Sci. 2016 Aug 25;91:131-7
pubmed: 27312477
J Biomater Sci Polym Ed. 2006;17(4):419-33
pubmed: 16768293
Food Chem Toxicol. 2011 Oct;49(10):2670-5
pubmed: 21787831
J Cosmet Dermatol. 2018 Dec;17(6):996-999
pubmed: 29316184
Biomacromolecules. 2011 Mar 14;12(3):824-30
pubmed: 21314111
Dermatol Surg. 2009 Feb;35 Suppl 1:302-12
pubmed: 19207319
J Biomed Mater Res A. 2010 Mar 1;92(3):1162-70
pubmed: 19322881
J Adv Res. 2015 Mar;6(2):105-21
pubmed: 25750745
J Biomater Sci Polym Ed. 2000;11(4):383-99
pubmed: 10903037
Eur J Med Res. 2016 Feb 13;21:5
pubmed: 26873038