Herpes simplex encephalitis: A new type of "ICU-acquired infection"?
Electrophysiology
Herpes simplex Encephalitis
Herpes simplex reactivation
ICU acquired Infection
Immunosuppression
Infectious disease
Intensive care
Intensive care medicine
Neurology
Neurosurgery
Journal
Heliyon
ISSN: 2405-8440
Titre abrégé: Heliyon
Pays: England
ID NLM: 101672560
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
received:
29
12
2019
revised:
17
03
2020
accepted:
23
03
2020
entrez:
8
4
2020
pubmed:
8
4
2020
medline:
8
4
2020
Statut:
epublish
Résumé
Although it is a well-known disease, the occurrence of Clinical observation of one patient. An 87-year-old male was admitted to the Intensive Care Unit (ICU) because of respiratory failure due to an exacerbation of myasthenia gravis. After corticoids and azathioprine treatment, his clinical condition improved, allowing weaning from mechanical ventilation. One month after admission, while still hospitalized in the ICU, the patient developed fever and confusion. In the context of confounding factors, HSE was not suspected before a convulsive status epilepticus occurred, resulting in a significant delay in treatment. Diagnosis was confirmed by PCR-analysis in the cerebrospinal fluid. Serological status confirmed reactivation of prior herpes simplex infection. The patient died one week after the onset of confusion. Hospital-"acquired" HSE must be suspected in case of new neurologic symptoms associated with fever, even in ICU-hospitalized patients. The diagnosis is made even more difficult by nonspecific symptoms due to previous diseases, leading to an even more severe prognosis in those vulnerable patients.
Identifiants
pubmed: 32258496
doi: 10.1016/j.heliyon.2020.e03667
pii: S2405-8440(20)30512-0
pii: e03667
pmc: PMC7113434
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e03667Informations de copyright
© 2020 Published by Elsevier Ltd.
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